Estimated Autism Risk and Older Reproductive Age

Dados Bibliográficos

ID11023909
AutoresMarissa King (0009-0000-6590-3567, Columbia University), Marissa D King (At the time of the study, the authors were with the Institute for Social and Economic Research and Policy, Columbia University, New York, NY. Christine Fountain was also with the Department of Sociology at the University of South Carolina, Columbia. Peter S. Bearman was also with the Department of Sociology, Columbia University, New York.), Christine Fountain (0000-0002-4742-886X, At the time of the study, the authors were with the Institute for Social and Economic Research and Policy, Columbia University, New York, NY. Christine Fountain was also with the Department of Sociology at the University of South Carolina, Columbia. Peter S. Bearman was also with the Department of Sociology, Columbia University, New York.), Diana Dakhlallah (0000-0001-5178-2741, At the time of the study, the authors were with the Institute for Social and Economic Research and Policy, Columbia University, New York, NY. Christine Fountain was also with the Department of Sociology at the University of South Carolina, Columbia. Peter S. Bearman was also with the Department of Sociology, Columbia University, New York.), P Bearman (0000-0002-3745-3164, Columbia University), Peter S Bearman (At the time of the study, the authors were with the Institute for Social and Economic Research and Policy, Columbia University, New York, NY. Christine Fountain was also with the Department of Sociology at the University of South Carolina, Columbia. Peter S. Bearman was also with the Department of Sociology, Columbia University, New York.)
Ano2009
Volume99
Fascículo9
Páginas1673-1679
Data de publicação2009-09-01
Peer ReviewedSim
Open AccessNão
TipoARTICLE
PeriódicoAmerican Journal of Public Health (JOURNAL)
Identificadores do periódicoISSN: 0090-0036 • E-ISSN: 1541-0048
EditoraAmerican Public Health Association (PUBLISHER • US)
DOI10.2105/ajph.2008.149021
PMID19608957
PMCIDPMC2724463
OpenAlexW2094236670
IdiomaEN
Citações recebidas13
Referências citadas22

Objectives. We sought to estimate the risk for autism associated with maternal and paternal age across successive birth cohorts. Methods. We linked birth records and autism diagnostic records from the California Department of Developmental Services for children born in California between 1992 and 2000 to calculate the risk associated with maternal and paternal age for each birth cohort as well as for the pooled data. Results. The categorical risks associated with maternal age over 40 years ranged from a high of 1.84 (95% confidence interval [CI] = 1.37, 2.47) to a low of 1.27 (95% CI = 0.95, 1.69). The risk associated with paternal age ranged from 1.29 (95% CI = 1.03, 1.6) to 1.71 (95% CI = 1.41, 2.08). Conclusions. Pooling data across multiple birth cohorts inflates the risk associated with paternal age. Analyses that do not suffer from problems produced by pooling across birth cohorts demonstrated that advanced maternal age, rather than paternal age, may pose greater risk. Future research examining parental age as a risk factor must be careful to avoid the paradoxes that can arise from pooling data, particularly during periods of social demographic change

Advanced maternal age · Autism · Biology · Birth records · Birth weight · Cohort · Cohort study · Confidence interval · Paternal age · Pooling · Pregnancy · Psychiatry · Risk factor · Autism Spectrum Disorder Research · Child Nutrition and Feeding Issues · Demography · Family and Disability Support Research · Genetics · Medicine