Education and the Risk of Alzheimer's Disease

Findings From the Study of Dementia in Swedish Twins

Dados Bibliográficos

ID12444451
AutoresMargaret Gatz (0000-0002-1071-9970, University of Southern California, autor correspondente), Pia Svedberg (0000-0001-7952-3418), Nancy L Pedersen (0000-0001-8057-3543), James A Mortimer, S Berg (0000-0002-4722-1973), Stéphanie M van den Berg (0000-0001-8154-1068), Boo Johansson (0000-0002-1996-3435)
Ano2001
Volume56
Fascículo5
PáginasP292-P300
Data de publicação2001-09-01
Peer ReviewedSim
Open AccessNão
TipoARTICLE
PeriódicoThe Journals of Gerontology Series B (JOURNAL)
Identificadores do periódicoISSN: 1079-5014 • E-ISSN: 1758-5368
EditoraOxford University Press (OUP) (PUBLISHER)
DOI10.1093/geronb/56.5.p292
PMID11522804
OpenAlexW2129133444
IdiomaEN
Citações recebidas14
Referências citadas3

The association between dementia and education was studied in 143 twin pairs discordant for dementia, using a matched-pair design, and in 221 dementia cases and 442 unrelated controls from the same twin registry, using a case-control design. Low education was defined as 6 years or less of schooling. Case-control analyses with prevalent cases showed low education to be a risk for Alzheimer's disease but not dementia in general. Low education did not significantly predict incident cases. In the matched-pairs analysis, which controls for genetic and other familial influences, differences in education between demented twins and twin partners were not statistically significant. However, for Alzheimer's disease, odds ratios resulting from matched pairs and case-control analyses were similar. Twins' comparative reports about intellectual involvement earlier in their lives suggest a long-standing difference on this dimension, with less involvement by the twin who became demented

Alzheimer's disease · Biology · Case-control study · Dementia · Developmental psychology · Disease · Odds ratio · Twin study · Alzheimer's disease research and treatments · Dementia and Cognitive Impairment Research · Folate and B Vitamins Research · Medicine · Psychology · Genetics · Gerontology · Internal Medicine · Pediatrics