Communities and Clinical Trials
A Case Study from the RTS,S Malaria Vaccine Trials in Eastern Africa
Dados Bibliográficos
| ID | 12806941 |
|---|---|
| Autores | Machteld van den Berg (0000-0001-7804-7560, University of Zurich, autor correspondente), Bernhards Ogutu (0000-0002-0992-5654, Strathmore University), Nelson K Sewankambo (0000-0001-9362-053X, Makerere University), Sonja Merten (0000-0003-4115-106X, University of Basel), Nikola Biller‐Andorno (0000-0001-7661-1324, University of Zurich), Marcel Tanner (0000-0002-1205-6971, University of Basel) |
| Ano | 2020 |
| Volume | 15 |
| Fascículo | 5 |
| Páginas | 465-477 |
| Data de publicação | 2020-08-26 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Journal of Empirical Research on Human Research Ethics (JOURNAL) |
| Identificadores do periódico | ISSN: 1556-2646 • E-ISSN: 1556-2654 |
| Editora | SAGE Publishing (PUBLISHER • US) |
| DOI | 10.1177/1556264620951384 |
| PMID | 32847469 |
| OpenAlex | W3080880567 |
| Idioma | EN |
| Citações recebidas | 1 |
| Referências citadas | 34 |
When clinical trials enter human communities, two complex systems merge-creating challenges for the clinical trial team and the local human community. This is of particular relevance for clinical trials in low-resource settings where the resource scarcity can intensify existing inequities. Here we present a case study of a phase III malaria vaccine clinical trial. Through qualitative interviews with researchers and caregivers of pediatric participants we elucidate themes that shape the clinical trial system. These themes can be a useful complementary planning tool to existing research guidelines for clinical trial researchers. Respondents from both groups reported financial and social contextual realities to be major drivers in the system. We found a strong historical path dependency in the community that was closely tied to the relationships with researchers and indicative of the structural inequities. We elaborate on these findings and offer recommendations to improve trial design
Clinical trial · Malaria · Malaria vaccine · Pathology · Qualitative research · Scarcity · Social science · Sociology · Workaround · Global Health and Surgery · Medicine · Mosquito-borne diseases and control · Psychology · Viral Infections and Outbreaks Research
Engaging ‘communities’
Social Emergence
The benefits of participatory methodologies to develop effective community dialogue in the context of a microbicide trial feasibility study in Mwanza, Tanzania
Rumours' and clinical trials
The ethics and politics of community engagement in global health research
From ‘trial community’ to ‘experimental publics’
Global Health
Adverse events and placebo effects
Immunization in Developing Countries
Ancillary Care in Community-Based Public Health Intervention Research
Complex adaptive systems as a valid framework for understanding community level development
Vaccinations in the third world
Kachinjaare Coming
The 'empty choice
Medical Anthropology in Africa
| Obras citantes distintas | 1 |
|---|---|
| Citações por ano | 1 |
| Intervalo de citações | 2026 - 2026 (1) |
| Velocidade de citação | current |
| Altamente citado | Não |
| Tipos de citação | Neutras: 1 |