Distribution of apolipoprotein E allele frequencies of the Han Chinese in an iodine-deficient mountainous area

Dados Bibliográficos

ID13922366
AutoresJianjun Gao (0000-0003-2720-0670, Shanghai Jiao Tong University, autor correspondente), Fuchang Zhang (Northwest University), Tingwei Guo (0000-0002-9320-543X, Shanghai Jiao Tong University), Xiaocai Gao (0000-0002-7269-5409, Northwest University), Shiwei Duan (0000-0001-7682-2877, Shanghai Jiao Tong University), Hongyan Wang (0000-0002-1754-4018, Shanghai Institutes for Biological Sciences), Zijian Zheng (0000-0003-1524-7658, Northwest University), Tiancai Huang (0009-0008-9436-7298), Tiezhu Huang, Guoyin Feng (Shanghai Mental Health Center), Darlene St Clair (0000-0002-5890-7292, University of Aberdeen), Lin He (0000-0001-9295-2217, Shanghai Jiao Tong University)
Ano2004
Volume31
Fascículo5
Páginas578-585
Data de publicação2004-09-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAnnals of Human Biology (JOURNAL)
Identificadores do periódicoISSN: 0301-4460 • E-ISSN: 1464-5033
EditoraInforma (PUBLISHER • GB)
DOI10.1080/03014460400007203
PMID15739386
OpenAlexW2028927651
IdiomaEN
Referências citadas12

The currently documented allele frequencies of ApoE in the Han Chinese population living in the open areas of China do not represent the distribution in the isolated Qinba mountainous area. The higher level of epsilon2 and epsilon4 allele frequencies in the Han Chinese living in the isolated Qinba area arise by chance or may result from genetic adaptation to an environment characterized by malnutrition and iodine deficiency, which may also contribute to the high incidence of mental retardation in these regions

Allele · Allele frequency · Apolipoprotein E · Biology · Disease · Environmental health · Gene · Genotype · Population · Folate and B Vitamins Research · Medicine · Pregnancy and preeclampsia studies · Thyroid Disorders and Treatments · Genetics · Internal Medicine