The activation of histone deacetylases 4 prevented endothelial dysfunction

A crucial mechanism of HuangqiGuizhiWuwu Decoction in improving microcirculation dysfunction in diabetes

Dados Bibliográficos

ID14735112
AutoresMeijiang Chen (Guangzhou University of Chinese Medicine), Hong Cheng (0009-0006-9669-8969, Guangzhou University of Chinese Medicine), Xinyi Chen (0000-0001-5084-7849, Guangzhou University of Chinese Medicine), Jiangyong Gu (0000-0002-3654-2640, Guangzhou University of Chinese Medicine), Weiwei Su (0000-0002-1303-6331, Sun Yat-sen University), Gaize Cai (Guangzhou University of Chinese Medicine), Yan Yue (0000-0002-4904-0711, Guangzhou University of Chinese Medicine), Yue Yan (0000-0001-9103-2806), Chen Wang (0000-0003-3042-291X, Guangzhou University of Chinese Medicine), Xiaoye Xia (Guangzhou University of Chinese Medicine), Kaitong Zhang (Guangzhou University of Chinese Medicine), Meng Zhang (0000-0002-4822-2273, Shandong University of Traditional Chinese Medicine), Haiqiang Jiang (0000-0003-3647-3865, Shandong University of Traditional Chinese Medicine), Yongjun Chen (0009-0005-8967-5366, Guangzhou University of Chinese Medicine, autor correspondente), Lin Yao (0000-0002-2123-7811, Guangzhou University of Chinese Medicine, autor correspondente)
Ano2023
Volume307
Páginas116240
Data de publicação2023-05-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Ethnopharmacology (JOURNAL)
Identificadores do periódicoISSN: 0378-8741 • E-ISSN: 1872-7573
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2023.116240
PMID36764560
OpenAlexW4319770544
IdiomaEN
Referências citadas47

These results prove the key role of HDAC4 in diabetes-induced microvascular dysfunction and underlying epigenetic mechanisms for the protective effect of HGWWD in diabetes

Acetylation · Biology · Diabetes mellitus · Endothelial Dysfunction · Epigenetics · HDAC3 · HDAC4 · HDAC6 · Histone · Histone deacetylase · Histone deacetylase 2 · Microcirculation · SIRT2 · Sirtuin · Biological and pharmacological studies of plants · Histone Deacetylase Inhibitors Research · Medicine · Sirtuins and Resveratrol in Medicine · Biochemistry · Endocrinology · Internal Medicine · Pharmacology