Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and Mapk axis in Alzheimer's disease
Dados Bibliográficos
| ID | 14735604 |
|---|---|
| Autores | Dongmei Chen (0000-0001-5419-8735, Fujian Medical University), Ruomeng Li (0000-0002-7278-1585, Fujian Medical University), Fei She (Fujian Medical University), Jiawen Chen (0000-0002-4747-3679, Fujian Medical University), Sang Min Cho (Institute of Aging), Bohyun Yang (0000-0003-0648-8214, Institute of Aging), Yuan Tian (0000-0002-0051-8788, Fujian Medical University), Le Guan, Le Luo Guan (0000-0002-8420-4371, Fujian Medical University), Xiuzhi Zheng (0000-0002-6633-9811, Fujian Medical University), Quling Wang (Fujian Medical University), Long Wang (0000-0001-5600-8157, Fujian Medical University), Sang Won Park (0000-0002-6149-5284, Boston Children's Hospital), Wucheng Tao (0000-0003-2577-8161, Fujian Medical University), Tao Zhang (0000-0002-4890-1671, Fujian Medical University, autor correspondente), Byeong Mo Kim (0000-0002-0582-3132, Institute of Aging, autor correspondente), Tae Ho Lee (0000-0003-2378-7793, Fujian Medical University, autor correspondente) |
| Ano | 2025 |
| Volume | 352 |
| Páginas | 120221 |
| Data de publicação | 2025-08-01 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Journal of Ethnopharmacology (JOURNAL) |
| Identificadores do periódico | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Editora | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2025.120221 |
| PMID | 40588144 |
| OpenAlex | W4411928258 |
| Idioma | EN |
| Citações recebidas | 1 |
| Referências citadas | 86 |
Our results suggest that SSc treatment ameliorates cognitive deficits and related tau pathological features in the hTau AD mouse model. The antioxidant effects of SSc might be responsible for the therapeutic potential of SSc in protecting against tau pathology and cognitive decline
Alzheimer's disease · Biology · Disease · GSK3B · Hippocampus · Inflammation · MAPK/ERK pathway · Morris water navigation task · Neurodegeneration · Neuroinflammation · Neuroprotection · Oxidative stress · Pathology · Phosphorylation · Protein kinase B · Tau protein · Tauopathy · Alzheimer's disease research and treatments · Medicine · Natural product bioactivities and synthesis · Neuroinflammation and Neurodegeneration Mechanisms · Neuroscience · Cell Biology · Internal Medicine · Pharmacology
Gene set enrichment analysis
Beneficial effects of the herbal medicine zuo gui wan in a mice model of Alzheimer's disease via Drp1-Mediated inhibition of mitochondrial fission and activation of AMPK/PGC-1α-regulated mitochondrial bioenergetics
A comprehensive review of bupleuri radix and its bioactive components
A strategy for evaluating antipyretic efficacy of Chinese herbal medicines based on UV spectra fingerprints
Neuroprotective effect of the traditional decoction Tian-Si-Yin against Alzheimer's disease via suppression of neuroinflammation
Multi-omics reveals the mechanisms of antidepressant-like effects of the low polarity fraction of Bupleuri Radix
Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress
| Obras citantes distintas | 1 |
|---|---|
| Citações por ano | 1 |
| Intervalo de citações | 2026 - 2026 (1) |
| Velocidade de citação | current |
| Altamente citado | Não |
| Tipos de citação | Neutras: 1 |