Uncovering the molecular mechanisms of Curcumae Rhizoma against myocardial fibrosis using network pharmacology and experimental validation

Dados Bibliográficos

ID14738599
AutoresMeng Zhang (0000-0002-4822-2273, Nanjing University of Chinese Medicine), Pengyu Lu (0009-0006-9812-1434, Nanjing University of Chinese Medicine), Fusen Zhao (0000-0002-9088-8191, Nanjing University of Chinese Medicine), Xuemei Sun (0000-0002-4501-7098, Hangzhou Hospital of Traditional Chinese Medicine), Wenqi Ma (0000-0003-1656-0953, Nanjing University of Chinese Medicine), Jiahui Tang (0000-0002-4933-527X), Chengbo Zhang (0009-0003-7872-4519, Nanjing University of Chinese Medicine), Haigang Ji (Hangzhou Hospital of Traditional Chinese Medicine, autor correspondente), Xindong Wang (0000-0003-1139-8838, Nanjing University of Chinese Medicine, autor correspondente)
Ano2023
Volume300
Páginas115751
Data de publicação2023-01-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Ethnopharmacology (JOURNAL)
Identificadores do periódicoISSN: 0378-8741 • E-ISSN: 1872-7573
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2022.115751
PMID36162550
OpenAlexW4296935155
IdiomaEN
Citações recebidas7
Referências citadas41

The findings suggested that Curcumae Rhizoma diminished myocardial fibrosis by suppressing fibrosis multiplication and collagen deposition through inhibiting p38 MAPK/NF-κB and TGF-β1/Smad2/3 pathways, which might be a promising therapeutic medicament for alleviating myocardial fibrosis

Biology · Cardiac fibrosis · Computational biology · Fibrosis · Gene · Gene expression · Gene ontology · In vitro · In vivo · KEGG · MAPK/ERK pathway · Mechanism of Action · Myocardial fibrosis · Pathology · Signal transduction · Cardiac Fibrosis and Remodeling · Chemistry · Galectins and Cancer Biology · Medicine · Signaling Pathways in Disease · Biochemistry · Pharmacology