Qingda granule ameliorates vascular remodeling and phenotypic transformation of adventitial fibroblasts via suppressing the TGF-β1/Smad2/3 pathway

Meizhu Wu; Siyu Zhang; Wenqiang Zhang; Yuting Zhou; Zhi Guo; Yi Fang; Yanyan Yang; Zhiqing Shen; Dawei Lian; Aling Shen; Jun Peng

doi:10.1016/j.jep.2023.116535

Qingda granule ameliorates vascular remodeling and phenotypic transformation of adventitial fibroblasts via suppressing the TGF-β1/Smad2/3 pathway

Dados Bibliográficos

ID	14739708
Autores	Meizhu Wu (0000-0003-2010-8644, Fujian University of Traditional Chinese Medicine), Siyu Zhang (0000-0002-7739-033X, Fujian University of Traditional Chinese Medicine), Wenqiang Zhang (0000-0002-0317-3914, Fujian University of Traditional Chinese Medicine), Yuting Zhou (0000-0003-2186-6404, Fujian University of Traditional Chinese Medicine), Zhi Guo (0009-0005-8029-2457, Fujian University of Traditional Chinese Medicine), Yi Fang (0000-0002-3001-7028, Fujian University of Traditional Chinese Medicine), Yanyan Yang (0000-0001-7551-6376, Fujian University of Traditional Chinese Medicine), Zhiqing Shen (Fujian University of Traditional Chinese Medicine), Dawei Lian (Fujian University of Traditional Chinese Medicine), Aling Shen (0000-0002-5081-3523, Fujian University of Traditional Chinese Medicine, autor correspondente), Jun Peng (0000-0001-7536-3613, Fujian University of Traditional Chinese Medicine, autor correspondente)
Ano	2023
Volume	313
Páginas	116535
Data de publicação	2023-09-01
Open Access	Sim
Tipo	ARTICLE
Periódico	Journal of Ethnopharmacology (JOURNAL)
Identificadores do periódico	ISSN: 0378-8741 • E-ISSN: 1872-7573
Editora	Elsevier BV (PUBLISHER)
DOI	10.1016/j.jep.2023.116535
PMID	37100260
OpenAlex	W4366831167
Idioma	EN
Referências citadas	30

QDG treatment attenuated hypertension-induced vascular remodeling of the abdominal aorta and phenotypic transformation of adventitial fibroblasts, at least partly by suppressing TGF-β1/Smad2/3 signaling

Biology · Blood pressure · Desmin · Gene expression · H&E stain · Immunohistochemistry · In vivo · KEGG · NADPH oxidase · NOX4 · Oxidative stress · Pathology · Staining · Transcriptome · Valsartan · Vascular smooth muscle · Angiogenesis and VEGF in Cancer · Chemistry · Connective Tissue Growth Factor Research · Medicine · TGF-β signaling in diseases · Biochemistry · Endocrinology · Internal Medicine · Pharmacology