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Investigating the mechanism of Rehmannia glutinosa–Ephedra sinica in heart failure with preserved ejection fraction by network pharmacology, metabolomics and experimental validation

Dados Bibliográficos

ID14744930
AutoresYu Cao (0000-0003-0624-7648, Shanghai University of Traditional Chinese Medicine), Sudan Li (Shanghai University of Traditional Chinese Medicine), Yi Zhang (0000-0002-7581-7061, Shanghai University of Traditional Chinese Medicine), Menghua He (Shanghai University of Traditional Chinese Medicine), Yan Shen (0009-0008-0461-5498, Shanghai University of Traditional Chinese Medicine, autor correspondente)
Ano2026
Volume364
Páginas121511
Data de publicação2026-06-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Ethnopharmacology (JOURNAL)
Identificadores do periódicoISSN: 0378-8741 • E-ISSN: 1872-7573
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121511
PMID41831736
OpenAlexW7135043741
IdiomaEN
Referências citadas80

Ejection fraction · Heart failure · Heart failure with preserved ejection fraction · Mechanism (biology · Metabolomics · Antioxidants, Aging, Portulaca oleracea · Biological and pharmacological studies of plants · Pharmacology and Obesity Treatment

  • Ferroptosis

    Open Access•Xuejun Jiang, Brent R Stockwell et al.•Nature Reviews Molecular Cell…•2021

  • Ling-Gui-Qi-Hua formula alleviates left ventricular myocardial fibrosis in rats with heart failure with preserved ejection fraction by blocking the transforming growth factor-β1 /Smads signaling pathway

    Open Access•Yujiao Shi, Chunqiu Liu et al.•Journal of Ethnopharmacology•2023

  • Rehmannia glutinosa

    Open Access•Ruxue Zhang, Ru-Xue Zhang et al.•Journal of Ethnopharmacology•2008

  • The anti-obesity effect of Ephedra sinica through modulation of gut microbiota in obese Korean women

    Bong-Soo Kim, Mi-young Song et al.•Journal of Ethnopharmacology•2014

  • Comparing steamed and wine-stewed Rehmanniae Radix in terms of Yin-nourishing effects via metabolomics and microbiome analysis

    Open Access•Xiaoya Zhang, Xiao-Ya Zhang et al.•Journal of Ethnopharmacology•2023

  • Investigation of the efficacy of Dengzhan Shengmai capsule against heart failure with preserved ejection fraction

    Open Access•Ziyi Kang, Yue Wu et al.•Journal of Ethnopharmacology•2024

  • Effects and mechanism of Compound Qidan Formula on rats with HFpEF induced by hypertension and diabetes mellitus based on Ang II/TGF-β1/Smads signaling pathway

    Open Access•Ping Yuan, Jiangang Liu et al.•Journal of Ethnopharmacology•2023

  • A systematic review on botany, processing, application, phytochemistry and pharmacological action of Radix Rehmnniae

    Open Access•MinMin Li, Huajuan Jiang et al.•Journal of Ethnopharmacology•2022

  • A comprehensive study of Ephedra sinica Stapf-Schisandra chinensis (Turcz.) Baill herb pair on airway protection in asthma

    Open Access•Zushun Zhuo, Jianhua Nie et al.•Journal of Ethnopharmacology•2024

  • Herb pair of Ephedrae Herba-Armeniacae Semen Amarum alleviates airway injury in asthmatic rats

    Open Access•Jia-xin Ma, Xiong Xiao et al.•Journal of Ethnopharmacology•2021

  • Multi-omics approach for identification of molecular alterations of QiShenYiQi dripping pills in heart failure with preserved ejection fraction

    Open Access•Yuting Huang, Kai Zhang et al.•Journal of Ethnopharmacology•2023

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