Ganoderic Acid A alleviates ulcerative colitis by inhibiting the interleukin17 signaling pathway via targeting retinoic acid-related orphan receptor alpha

Dados Bibliográficos

ID14744980
AutoresYifei Ye (0009-0003-8404-5854, Nanchang University), Yinni Chen (Hefei University of Technology), Yiyang Cao (0009-0004-0061-6494, First Affiliated Hospital of Jiangxi Medical College), T Liu (0000-0002-3568-4882, First Affiliated Hospital of Jiangxi Medical College), Yu Hu (0000-0001-8388-0696, Jiang Xi Institute for Drug Control), Xi Chen (0000-0002-2058-0351, First Affiliated Hospital of Jiangxi Medical College, autor correspondente), Xiangnuo Han (First Affiliated Hospital of Jiangxi Medical College), Shu Yang (0000-0001-7274-8497, Peking University Shenzhen Hospital), Shun Li (0000-0003-1102-5572, Anhui Academy of Medical Sciences, autor correspondente), Yuanli Chen (0000-0003-0813-3847, Hefei University of Technology), Meixiu Jiang (0000-0001-8747-6877, Jiangxi University of Technology, autor correspondente)
Ano2026
Volume361
Páginas121297
Data de publicação2026-04-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoJournal of Ethnopharmacology (JOURNAL)
Identificadores do periódicoISSN: 0378-8741 • E-ISSN: 1872-7573
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.jep.2026.121297
PMID41621760
OpenAlexW7126187034
IdiomaEN
Referências citadas60

Our findings disclose that GAA alleviated DSS-induced UC by inhibiting the IL-17 signaling pathway via targeting RORA to reduce inflammation. Our study suggests that GAA holds potential as a nutritional intervention for the prevention and treatment of UC

Alpha (finance · Colitis · Orphan receptor · Receptor · Retinoic acid · Signal transduction · Tretinoin · Ulcerative colitis · Inflammatory Bowel Disease · Psoriasis: Treatment and Pathogenesis · Retinoids in leukemia and cellular processes