Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression
The role of TRAF6 in diabetic nephropathy
Dados Bibliográficos
| ID | 14745976 |
|---|---|
| Autores | Wu Luo (0000-0001-7383-9470, Wenzhou Medical University), Xiaojun Chen (0000-0002-2818-4652, Wenzhou Medical University), Lin Ye (0000-0002-4199-1694), Ye Lin (0000-0002-0750-8996, Wenzhou Medical University), Xuemei Chen (0000-0002-4087-9676, Wenzhou Medical University), Wenjing Jia (0000-0001-8938-9515, Wenzhou Medical University), Yanni Zhao (0009-0002-3903-2977, Wenzhou Medical University), Aleksandr V Samorodov (0000-0001-9302-499X, Bashkir State Medical University), Yali Zhang (0000-0002-2599-3710, Wenzhou Medical University), Xueting Hu (Wenzhou Medical University), Fei Zhuang (0000-0002-2332-6543, Wenzhou Medical University), Jianchang Qian (0000-0001-9985-3852, Wenzhou Medical University), Chao Zheng (0000-0002-2779-0255, Wenzhou Medical University), Guang Liang (0000-0002-8278-849X, Wenzhou Medical University, autor correspondente), Yi Wang (0000-0003-2228-7009, Wenzhou Medical University, autor correspondente) |
| Ano | 2021 |
| Volume | 268 |
| Páginas | 113553 |
| Data de publicação | 2021-03-01 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Journal of Ethnopharmacology (JOURNAL) |
| Identificadores do periódico | ISSN: 0378-8741 • E-ISSN: 1872-7573 |
| Editora | Elsevier BV (PUBLISHER) |
| DOI | 10.1016/j.jep.2020.113553 |
| PMID | 33152432 |
| OpenAlex | W3095864827 |
| Idioma | EN |
| Citações recebidas | 3 |
| Referências citadas | 36 |
Our findings provide direct evidence that TRAF6 mediates diabetes-induced inflammation leading to renal dysfunction. We also show that KPF is a potential therapeutic agent to reduce inflammatory responses in DN. Also, TRAF6 may represent an interesting target to combat DN
Apoptosis · Diabetes mellitus · Diabetic nephropathy · Downregulation and upregulation · Gene knockdown · Inflammation · Kidney · Proinflammatory cytokine · Streptozotocin · Chemistry · Liver Disease Diagnosis and Treatment · Medicine · NF-κB Signaling Pathways · Pancreatitis Pathology and Treatment · Biochemistry · Endocrinology · Immunology · Pharmacology
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| Obras citantes distintas | 3 |
|---|---|
| Citações por ano | 0,75 |
| Intervalo de citações | 2022 - 2024 (3) |
| Velocidade de citação | recent |
| Altamente citado | Não |
| Tipos de citação | Neutras: 3 |