The “Missing Heritability” of Psychiatric Disorders
Elusive Genes or Non-Existent Genes
Dados Bibliográficos
| ID | 15029397 |
|---|---|
| Autores | Jay Joseph (0000-0001-6848-4150, Oakland Museum of California, autor correspondente) |
| Ano | 2012 |
| Volume | 16 |
| Fascículo | 2 |
| Páginas | 65-83 |
| Data de publicação | 2012-04-01 |
| Peer Reviewed | Sim |
| Open Access | Não |
| Tipo | ARTICLE |
| Periódico | Applied Developmental Science (JOURNAL) |
| Identificadores do periódico | ISSN: 1088-8691 • E-ISSN: 1532-480X |
| Editora | Informa UK Limited (PUBLISHER • GB) |
| DOI | 10.1080/10888691.2012.667343 |
| OpenAlex | W2008982173 |
| Idioma | EN |
| Citações recebidas | 1 |
| Referências citadas | 76 |
The psychiatric genetics field is currently undergoing a crisis due to the decades-long failure to uncover the genes believed to cause the major psychiatric disorders. Since 2009, leading researchers have explained these negative results on the basis of the “missing heritability” argument, which holds that more effective research methods must be developed to uncover presumed missing genes. According to the author, problems with the missing heritability argument include genetic determinist beliefs, a reliance on twin research, the use of heritability estimates, and the failure to seriously consider the possibility that presumed genes do not exist. The author concludes that decades of negative results support a finding that genes for the major psychiatric disorders do not appear to exist, and that research attention should be directed away from attempts to uncover “missing heritability” and toward environmental factors and a reassessment of previous genetic interpretations of psychiatric family, twin, and adoption studies
Argument (complex analysis · Behavioural genetics · Biology · Determinism · Developmental psychology · Epistemology · Gene · Genetic variants · Heritability · Missing heritability problem · Psychiatric genetics · Psychiatry · Schizophrenia (object-oriented programming · Twin study · Child and Adolescent Psychosocial and Emotional Development · Cognitive Abilities and Testing · Genetic Associations and Epidemiology · Medicine · Psychology · Genetics
Creating Mental Illness
The limits of family influence
Heredity, Environment, and Personality
Sources of Human Psychological Differences
Finding the missing heritability of complex diseases
Three Laws of Behavior Genetics and What They Mean
Genetic and environmental influences on human psychological differences
Intelligence
Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys
The Nazi Symbiosis
Not in Their Genes
Nature, Nurture, and Attention Deficit Hyperactivity Disorder
Not in Our Genes
Insanity
Do parents create, or respond to, differences in twins
The American Journal of Human Genetics
A Genetic Basis for Social Trust
Political Science, Biometric Theory, and Twin Studies
Beyond Liberals and Conservatives to Political Genotypes and Phenotypes
Genes and Ideologies
Politics, Genetics, and “Greedy Reductionism
Biology, Ideology, and Epistemology
Adoption results for self-reported personality
How much can a large population study on genes, environments, their interactions and common diseases contribute to the health of the American people
Contributions of twin research to psychology
Psychiatric Genetics in Munich and Basel between 1925 and 1945
| Obras citantes distintas | 1 |
|---|---|
| Citações por ano | 0,07 |
| Intervalo de citações | 2012 - 2012 (1) |
| Velocidade de citação | historical |
| Altamente citado | Não |
| Tipos de citação | Neutras: 1 |