Investigation of vitamin D status and its correlation with insulin resistance in a Chinese population

Objective Although many studies worldwide have focused on the relationship between vitamin D and insulin resistance, results remain controversial. Furthermore, concentrations of serum 25-hydroxyvitamin D (25(OH)D) in the Chinese population are unclear. We aimed to investigate vitamin D status and its correlation with insulin resistance among a Chinese adult population. Design Serum 25(OH)D, fasting blood glucose, fasting insulin, glycated Hb (HbA1c) and other metabolic parameters were assessed. Neck circumference, waist circumference, hip circumference, weight and height were also measured. Lifestyle factors including smoking and drinking status were obtained. Diabetes mellitus was diagnosed by HbA1c according to the 2010 American Diabetes Association criteria. Setting Eastern China. Subjects Of 7200 residents included, 6597 individuals were ultimately analysed. Results We enrolled 2813 males (mean age 52·7 ( sd 13·5) years) and 3784 females (52·3 ( sd 13·5) years); mean serum 25(OH)D concentration was 43·1 ( sd 11·6) and 39·6 ( sd 9·8) nmol/l, respectively. Additionally, 83·3 % of participants were 25(OH)D deficient. A significant difference in 25(OH)D was observed between males and females in winter and spring ( P 0·001). Furthermore, 25(OH)D concentrations were inversely associated with the homeostasis model assessment of insulin resistance (HOMA-IR) in the overweight and pre-diabetic populations. After adjusting for several variables, 25(OH)D was significantly associated with HOMA-IR in winter. When 25(OH)D values were categorized into quartiles, HOMA-IR was significantly associated with decreasing 25(OH)D. Conclusions The majority of the Chinese population was vitamin D deficient and this deficiency was negatively associated with insulin resistance, particularly in the overweight and pre-diabetic populations. Moreover, these associations might be more evident in the winter

Confidence interval · Diabetes mellitus · Glycated hemoglobin · Insulin · Insulin resistance · Obesity · Overweight · Population · Quartile · Type 2 diabetes · Vitamin D and neurology · vitamin D deficiency · Waist · Diet and metabolism studies · Medicine · Nutritional Studies and Diet · Vitamin D Research Studies · Endocrinology · Internal Medicine

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  Open Access•American Diabetes Association•Diabetes Care•2010

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