Inflammatory Biomarkers Differ among Hospitalized Veterans Infected with Alpha, Delta, and Omicron Sars-CoV-2 Variants

Dados Bibliográficos

ID15463539
AutoresCatherine Park (0000-0002-6137-5098, Michael E. DeBakey VA Medical Center), Shahriar Tavakoli–Tabasi (Baylor College of Medicine), Shahriar Tavakoli-Tabasi (Baylor College of Medicine), Amir Sharafkhaneh (0000-0002-7893-2946, Michael E. DeBakey VA Medical Center, autor correspondente), Benjamin Seligman (0000-0002-8223-5924, University of California, Los Angeles), Benjamin J Seligman (University of California, Los Angeles), Bret Hicken (0000-0002-1000-8773, George E. Wahlen Department of VA Medical Center), Christopher I Amos (0000-0002-8540-7023, Baylor College of Medicine), Andrew Chou (0000-0002-2520-6959, Michael E. DeBakey VA Medical Center), Javad Razjouyan (0000-0003-1157-159X, Michael E. DeBakey VA Medical Center)
Ano2023
Volume20
Fascículo4
Páginas2987-2987
Data de publicação2023-02-08
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoInternational Journal of Environmental Research and Public Health (JOURNAL)
Identificadores do periódicoISSN: 1661-7827 • E-ISSN: 1660-4601
EditoraMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph20042987
PMID36833680
OpenAlexW4319761808
IdiomaEN
Referências citadas30

Mortality due to COVID-19 has been correlated with laboratory markers of inflammation, such as C-reactive protein (CRP). The lower mortality during Omicron variant infections could be explained by variant-specific immune responses or host factors, such as vaccination status. We hypothesized that infections due to Omicron variant cause less inflammation compared to Alpha and Delta, correlating with lower mortality. This was a retrospective cohort study of veterans hospitalized for COVID-19 at the Veterans Health Administration. We compared inflammatory markers among patients hospitalized during Omicron infection with those of Alpha and Delta. We reported the adjusted odds ratio (aOR) of the first laboratory results during hospitalization and in-hospital mortality, stratified by vaccination status. Of 2,075,564 Veterans tested for COVID-19, 29,075 Veterans met the criteria: Alpha (45.1%), Delta (23.9%), Omicron (31.0%). Odds of abnormal CRP in Delta (aOR = 1.85, 95% CI:1.64-2.09) and Alpha (aOR = 1.94, 95% CI:1.75-2.15) were significantly higher compared to Omicron. The same trend was observed for Ferritin, Alanine aminotransferase, Aspartate aminotransferase, Lactate dehydrogenase, and Albumin. The mortality in Delta (aOR = 1.92, 95% CI:1.73-2.12) and Alpha (aOR = 1.68, 95% CI:1.47-1.91) were higher than Omicron. The results remained significant after stratifying the outcomes based on vaccination status. Veterans infected with Omicron showed milder inflammatory responses and lower mortality than other variants

Coronavirus disease 2019 (COVID-19 · Disease · Odds ratio · Vaccination · COVID-19 Clinical Research Studies · Long-Term Effects of COVID-19 · Medicine · SARS-CoV-2 and COVID-19 Research · Gastroenterology · Immunology · Internal Medicine