Constitutional Factors and Irradiation as Risk Factors for Thymoma

A European Case–Control Study

Dados Bibliográficos

ID15465441
AutoresLinda Kærlev (0000-0002-4157-9819, University of Southern Denmark, autor correspondente), Mikael Eriksson (0000-0001-8135-4270, Lund University), Pascal Guénel (0000-0002-8359-518X, Inserm), Franco Merletti (0000-0001-8846-7454, University of Turin), María Morales‐Suárez‐Varela (0000-0003-0785-1492, Universitat de València), Wolfgang Ahrens (0000-0003-3777-570X, Leibniz Institute for Prevention Research and Epidemiology - BIPS), Karl-Heinz Jöckel (0000-0002-1987-0255, Institut für Medizinische Informatik, Biometrie und Epidemiologie), Agustín Llopis González (0000-0001-8701-6918, Universitat de València), Gun Wingren (0000-0002-8234-5461, Linköping University), Lorenzo Simonato (0000-0002-9914-1000, University of Padua)
Ano2024
Volume21
Fascículo9
Páginas1241-1241
Data de publicação2024-09-20
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoInternational Journal of Environmental Research and Public Health (JOURNAL)
Identificadores do periódicoISSN: 1661-7827 • E-ISSN: 1660-4601
EditoraMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph21091241
PMID39338125
OpenAlexW4402688677
IdiomaEN
Referências citadas27

Little is known about the aetiology of thymoma. This study aims to identify medical risk factors for thymoma as a systematic approach to new hypotheses on the aetiology of this disease. A European multi-centre case-control study was conducted from 1995 to 1997, including incident cases aged 35-69 years with thymoma. Altogether, we accepted 85 cases and 3350 controls, of which we interviewed 77 cases and 2071 population controls about constitutional factors, medical examinations, and former diseases. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated. Medical examinations with X-ray or radiotherapy performed >20 times at least one year before the thymoma diagnosis indicated a possible risk factor for thymoma (OR 1.58, 95% CI 0.93-2.69). Having the first radiotherapy treatment at least one year before the thymoma diagnosis yielded an OR for thymoma of 2.39; 95% CI (0.96-5.99), and if it was at least five years before, the OR for thymoma was 2.81; 95% CI (1.03-7.72). Having a red/auburn hair colour was associated with thymoma, (OR 3.6, 95% CI 1.4-9.5) whereas having pigmented skin was slightly associated with thymoma (OR 1.8, 95% CI 0.8-3.8). Over twenty instances of X-ray examinations or radiotherapy were identified as potential risk factors for thymoma, along with certain constitutional factors. The observed correlations between benign tumours and thymoma could stem from an inherent predisposition to tumour development or result from detection bias. Given that this is the initial analytical study examining medical risk factors for thymoma, all of the results should be approached with caution, acknowledging the possibility that some findings might be incidental

Etiology · Odds ratio · Population · Radiation therapy · Risk factor · Thymoma · Medicine · Meningioma and schwannoma management · Myasthenia Gravis and Thymoma · Pituitary Gland Disorders and Treatments · Internal Medicine · Surgery