Effect of Oral Administration of Lactiplantibacillus plantarum SNK12 on Temporary Stress in Adults

A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Study

Dados Bibliográficos

ID15469645
AutoresTakumi Watanabe (0000-0002-4607-0747, Jichi Medical University, autor correspondente), Kyoko Hayashi (0000-0002-9582-1201, Chubu University), Tsuyoshi Takara (Takara (Japan)), Takumi Teratani (0000-0001-9923-0305, Jichi Medical University), Joji Kitayama (0000-0002-5708-7130, Jichi Medical University), Toshio Kawahara (0000-0003-0168-5825, Chubu University)
Ano2022
Volume19
Fascículo15
Páginas8936-8936
Data de publicação2022-07-22
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoInternational Journal of Environmental Research and Public Health (JOURNAL)
Identificadores do periódicoISSN: 1661-7827 • E-ISSN: 1660-4601
EditoraMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph19158936
PMID35897310
OpenAlexW4286587490
IdiomaEN
Referências citadas53

Mouse studies have reported anti-stress effects of Lactiplantibacillus plantarum SNK12 (SNK). Specifically, oral SNK administration increased mRNA levels of hippocampal neurotrophic factor and gamma-aminobutyric acid receptor in mice with sub-chronic mild stress-induced social defeat; moreover, it improved depressive behavior. We aimed to evaluate the efficacy of SNK ingestion against stress in healthy adults. We used the Uchida-Kraepelin test for the stress load, with a low-dose (50 mg/day), high-dose (150 mg/day), and placebo groups (dextrin). The primary outcome was the psychological evaluation as measured by the Profile of Mood States 2nd Edition (POMS2) using total mood disturbance (TMD) scores. The secondary outcomes were the score of each POMS2 item, salivary cortisol as a stress marker, and autonomic balance with the low frequency (LF)/ high frequency (HF) ratio. Compared with the placebo group, the SNK ingestion group showed significantly lower TMD scores. Additionally, compared with the placebo group, the high-dose group showed significantly lower scores for Tension-Anxiety and Confusion-Bewilderment, while the low-dose group showed significantly lower Anger-Hostility scores, salivary cortisol levels, and LF/HF scores. Our findings suggest that SNK ingestion could relieve stress (negative feelings, anxiety, tension, embarrassment, confusion, anger, and hostility) resulting from the temporary load caused by work and study

Anger · Anxiety · Hostility · Ingestion · Mood · Placebo · Psychiatry · Clinical Psychology · Medicine · Neuroendocrine regulation and behavior · Psychology · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Internal Medicine