Analysis of Benzene Exposure in Gas Station Workers Using Trans,Trans-Muconic Acid

Dados Bibliográficos

ID15487516
AutoresBárbara Rodrigues Geraldino (0000-0002-7061-1574, Universidade Federal do Rio de Janeiro, autor correspondente), Rafaella Ferreira Nascimento Nunes (0000-0001-6287-4748, Universidade Federal do Rio de Janeiro), Juliana Barroso Gomes (0000-0003-0837-6283, Universidade Federal do Rio de Janeiro), Isabela Giardini (0000-0001-9815-1832, Instituto Nacional de Câncer - INCA), Paula Vieira Baptista da Silva (0000-0002-9450-5370, Instituto Nacional de Câncer - INCA), Élida Campos (0000-0003-1604-8845, Instituto Nacional de Câncer - INCA), Katia Soares da Poça (0000-0002-8121-8700, Universidade Federal do Rio de Janeiro), Rocı́o Hassan (0000-0003-3782-3580, Instituto Nacional de Câncer - INCA), Ubirani Barros Otero (0000-0003-1464-2410, Instituto Nacional de Câncer - INCA), Marcia Sarpa (0000-0001-8976-4653, Universidade Federal do Rio de Janeiro)
Ano2020
Volume17
Fascículo15
Páginas5295-5295
Data de publicação2020-07-23
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoInternational Journal of Environmental Research and Public Health (JOURNAL)
Identificadores do periódicoISSN: 1661-7827 • E-ISSN: 1660-4601
EditoraMultidisciplinary Digital Publishing Institute (PUBLISHER • CH)
DOI10.3390/ijerph17155295
PMID32717818
OpenAlexW3044956283
IdiomaEN
Citações recebidas4
Referências citadas5

In Brazil, gas station workers are occupationally exposed to the benzene present in gasoline. Brazilian law indicates the use of trans,trans-muconic acid(t,t-MA) as a biomarker of benzene exposure. The aim of this study was to evaluate the level of exposure to benzene in gas station workers, through the quantification of t,t-MA present in urine. A total number of 269 gas station workers divided into 179 filling station attendants exposed by inhalation and dermal route and 90 convenience store workers exposed only by inhalation were included. A control group was formed by 100 office workers, without occupational exposure to benzene. The urinary levels of t,t-MA were evaluated by HPLC with a UV detector. Gas station workers showed higher mean values of t,t-MA (0.204 mg/g creatinine; 95% CI 0.170-0.237) than office workers (0.126 mg/g creatinine; 95% CI 0.0817-0.1693). T,t-MA levels were higher in convenience store workers exposed to gasoline only by inhalation (0.221 mg/g creatinine; 95% CI 0.160-0.282), than in those exposed to gasoline by inhalation and dermal route-filling station attendants (0.195 mg/g creatinine; 95% CI 0.155-0.235). Gas station workers with a higher level of t,t-MA had epistaxis. T,t-MA values were higher in the Downtown (0.15 mg/g creatinine) region's workers than in the more affluent South Zone region's workers (0.07 mg/g creatinine). Smoking habits influenced the urinary t,t-MA values, while the frequency of consumption of industrialized and frozen foods showed no influence

Benzene · Chromatography · Gas chromatography · Medicinal chemistry · Muconic acid · Air Quality and Health Impacts · Carcinogens and Genotoxicity Assessment · Chemistry · Indoor Air Quality and Microbial Exposure · Environmental Chemistry · Organic Chemistry