The Effect of High-Frequency Repetitive Transcranial Magnetic Stimulation on Emotion Processing, Reappraisal, and Craving in Alcohol Use Disorder Patients and Healthy Controls

A Functional Magnetic Resonance Imaging Study

Dados Bibliográficos

ID15517005
AutoresJochem M Jansen (0000-0001-9512-1259, University of Amsterdam, autor correspondente), Odile A Van Den Heuvel (0000-0002-9804-7653, Amsterdam Neuroscience), Ysbrand D van der Werf (0000-0003-2370-9584, Amsterdam Neuroscience), Stella J de Wit (0000-0002-5963-293X, Amsterdam Neuroscience), Dick J Veltman (0000-0001-8971-4250, Amsterdam University Medical Centers), Wim Van Den Brink (0000-0001-8301-0121, Amsterdam Institute for Addiction Research), A E Goudriaan (0000-0001-8670-9384, Amsterdam University Medical Centers)
Ano2019
Volume10
Páginas272-272
Data de publicação2019-05-07
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 1664-0640 • E-ISSN: 1664-0640
EditoraFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2019.00272
PMID31133889
OpenAlexW2944712042
IdiomaEN
Citações recebidas1
Referências citadas61

Impaired cognitive-motivational functioning is present in many psychiatric disorders, including alcohol use disorder (AUD). Emotion regulation is a key intermediate factor, relating to the (cognitive) regulation of emotional and motivational states, such as in regulation of craving or negative emotions that may lead to relapse in alcohol use. These cognitive-motivational functions, including emotion regulation, are a target in cognitive behavioral therapy and may possibly be improved by neurostimulation techniques. The present between-subjects, single-blind study assesses the effects of sham-controlled high-frequency neuronavigated repetitive transcranial magnetic stimulation (10 Hz) of the right dorsolateral prefrontal cortex (dlPFC) on several aspects relevant for emotion regulation (emotion processing and reappraisal abilities) and related brain activity, as well as self-reported craving in a sample of alcohol use disorder patients (AUD; n = 39) and healthy controls (HC; n = 36). During the emotion reappraisal task, participants were instructed to either attend or reappraise their emotions related to the negative, positive, neutral, and alcohol-related images, after which they rated their experienced emotions. We found that repetitive transcranial magnetic stimulation (rTMS) reduces self-reported experienced emotions in response to positive and negative images in AUD patients, whereas experienced emotions were increased in response to neutral and positive images in HCs. In the functional magnetic resonance imaging (fMRI) analyses, we found that rTMS reduces right dlPFC activity during appraisal of affective images relative to sham stimulation only in AUD patients. We could not confirm our hypotheses regarding the effect of rTMS craving levels, or on reappraisal related brain function, since no significant effects of rTMS on craving or reappraisal related brain function were found. These findings imply that rTMS can reduce the emotional impact of images as reflected in blood oxygenation level-dependent (BOLD) response, especially in AUD patients. Future studies should replicate and expand the current study, for instance, by assessing the effect of multiple stimulation sessions on both explicit and implicit emotion regulation paradigms and craving, and assess the effect of rTMS within subgroups with specific addiction-relevant image preferences. Clinical Trial Registration: www.ClinicalTrials.gov, identifier NCT02557815

Addiction · Alcohol · Alcohol use disorder · Audiology · Cognition · Cognitive reappraisal · Craving · Functional magnetic resonance imaging · Neuroimaging · Stimulation · Transcranial magnetic stimulation · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Neural and Behavioral Psychology Studies · Neuroscience · Psychology · Transcranial Magnetic Stimulation Studies