Sex Differences in the Association of Homa-IR Index and BDNF in Han Chinese Patients With Chronic Schizophrenia
Dados Bibliográficos
| ID | 15519081 |
|---|---|
| Autores | Yating Yang (0000-0002-2639-3944, Anhui Medical University), Yulong Zhang (0000-0003-4912-0487, Chaohu Hospital of Anhui Medical University), Juan Wang (0000-0001-8330-6707, Fourth People's Hospital of Sichuan Province), Xiaoshuai Ning (Chaohu Hospital of Anhui Medical University), Yelei Zhang (0009-0003-3516-7871, Anhui Medical University), Tongtong Zhao (0000-0001-9649-1526, Chaohu Hospital of Anhui Medical University), Yi Zhong (0000-0002-1411-2711, Hangzhou Seventh Peoples Hospital), Yuwen Zhong (0009-0000-8183-838X, Hangzhou Seventh Peoples Hospital), Zhiwei Liu (0000-0003-4241-0326), Lei Xia (0000-0001-7726-968X, Anhui Medical University), Wenzheng Li (0000-0003-2895-5434, Huai'an City Fourth People's Hospital), Xianhu Yao, Kai Zhang (0000-0002-7401-2931, Anhui Medical University, autor correspondente), Huanzhong Liu (0000-0002-6774-3998, Chaohu Hospital of Anhui Medical University, autor correspondente) |
| Ano | 2021 |
| Volume | 12 |
| Páginas | 656230-656230 |
| Data de publicação | 2021-06-21 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Frontiers in Psychiatry (JOURNAL) |
| Identificadores do periódico | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editora | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2021.656230 |
| PMID | 34234699 |
| OpenAlex | W3176258288 |
| Idioma | EN |
| Citações recebidas | 1 |
| Referências citadas | 68 |
Background: Previous research has indicated that there are significant sex differences in serum BDNF levels and metabolic indicators in patients with schizophrenia. Studies have found that BDNF is involved in blood sugar regulation. Homeostasis model assessment of insulin resistance (HOMA-IR) is currently a sensitive indicator for measuring insulin resistance. Our study aims to explore the sex differences in the relationship between serum BDNF levels and HOMA-IR in patients with chronic schizophrenia (CS). Methods: A total of 332 patients with CS were enrolled in this study. General information of all participants was collected. Haematological indicators were collected, and the Positive and Negative Syndrome Scale (PANSS) was used to evaluate psychiatric symptoms. Sex differences in serum BDNF levels, HOMA-IR index and other metabolic indexes were investigated. Then, linear regression analysis was used to analyse the relationship between the HOMA-IR index and BDNF levels in male and female patients. Results: The HOMA-IR index of female patients was significantly higher than that of males, but there was no significant difference in serum BDNF levels between male patients and female patients. There was a positive correlation between BDNF level and HOMA-IR index, and this relationship only existed in female patients. Conclusion: The results show that there are significant sex differences in HOMA-IR in patients with CS. In addition, only in female patients was there a positive correlation between the HOMA-IR index and BDNF level, which suggests that sex factors should be taken into account in evaluating the relationship between BDNF and blood glucose in patients with CS
Correlation · Homeostatic model assessment · Insulin · Insulin resistance · Positive and Negative Syndrome Scale · Psychiatry · Psychosis · Schizophrenia (object-oriented programming · Medicine · Regulation of Appetite and Obesity · Schizophrenia research and treatment · Tryptophan and brain disorders · Endocrinology · Internal Medicine
| Obras citantes distintas | 1 |
|---|---|
| Citações por ano | 0,25 |
| Intervalo de citações | 2022 - 2022 (1) |
| Velocidade de citação | historical |
| Altamente citado | Não |
| Tipos de citação | Neutras: 1 |