Impulsivity and Response Inhibition Related Brain Networks in Adolescents With Internet Gaming Disorder

A Preliminary Study Utilizing Resting-State fMRI

Dados Bibliográficos

ID15519454
AutoresJieyu Chen (0000-0002-4087-7654, Guiyang Medical University), Xinyi Li (0000-0002-4346-066X, Guiyang Medical University), Qun Zhang (0000-0002-0918-0832, Guizhou Normal University), Yu Zhou (0009-0001-5712-6902, Guizhou Provincial People's Hospital), Rongpin Wang (0000-0001-7587-4181, Guizhou Provincial People's Hospital), Chong Tian (0000-0002-3231-9409, Guizhou Provincial People's Hospital), Hui Xiang (0000-0002-3166-2299, Guizhou Provincial People's Hospital, autor correspondente)
Ano2021
Volume11
Páginas618319-618319
Data de publicação2021-01-15
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 1664-0640 • E-ISSN: 1664-0640
EditoraFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2020.618319
PMID33519558
OpenAlexW3120636761
IdiomaEN
Citações recebidas8
Referências citadas48

Background and Aims: Internet gaming disorder (IGD), as a relapse disease, has become a common mental health problem among Asian teenagers. Functional connections in the prefrontal lobo-striatum affect changes in impulsivity and inhibition. Therefore, exploration of the directional connections of the relevant brain regions in the prefrontal-striatal circuit and the synchronization level of the two hemispheres will help us to further understand the neural mechanism of IGD, which can provide guidance for the development of prevention and intervention strategies. Methods: Twenty-two adolescents with IGD, recruited through various channels, composed the IGD group. Twenty-six subjects, matching age, gender, and education level, were included in a recreational internet game users (RGUs) control group. Impulsivity and response inhibition were tested via general questionnaire, the Internet Addiction Test (IAT), the Barratt impulsivity scale-11 (BIS-11), and a Stroop color-word task. A Granger causality analysis (GCA) was used to calculate the directional connection between the prefrontal and striatum with the dorsolateral prefrontal cortex (DLPFC) as a region of interest (ROI). We chose voxel-mirrored homotopic connectivity (VMHC) to determine brain hemisphere functional connectivity in the prefrontal-striatal circuits. Results: We found significant differences in impulsivity between the IGD group and RGU group, with members of the IGD group exhibiting higher impulsivity. Additionally, the response inhibition of adolescents with IGD in the Stroop color-word task was impaired. There was a significant difference in the directed connection of the left DLPFC and dorsal striatum between the IGD group and the RGU group. Conclusions: This study confirmed the role of prefrontal-striatal circuits in the neural mechanism of IGD in adolescents. In the IGD group, bilateral cerebral medial orbitofrontal cortex (mOFC) synchronization was significantly reduced, which indicated that mOFC signal transmission in both hemispheres of the brain might be affected by impulse behavior and impaired response inhibition

Addiction · Anterior cingulate cortex · Cognition · Dorsolateral prefrontal cortex · Immunoglobulin D · Impulsivity · Prefrontal cortex · Resting state fMRI · Striatum · Stroop effect · Ventral striatum · Clinical Psychology · Functional Brain Connectivity Studies · Impact of Technology on Adolescents · Medicine · Mental Health Research Topics · Neuroscience · Psychology