Gray Matter Volumetric Abnormalities Associated with the Onset of Psychosis
Dados Bibliográficos
| ID | 15519517 |
|---|---|
| Autores | Wi Hoon Jung (0000-0002-8697-9584, Seoul National University, autor correspondente), Stefan Borgwardt (0000-0002-5792-3987, University of Cambridge), P Fusar‐poli (0000-0003-3582-6788, University of Cambridge), Jun Soo Kwon (0000-0002-1060-1462, Seoul National University Hospital) |
| Ano | 2012 |
| Volume | 3 |
| Páginas | 101-101 |
| Data de publicação | 2012-01-01 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Frontiers in Psychiatry (JOURNAL) |
| Identificadores do periódico | ISSN: 1664-0640 • E-ISSN: 1664-0640 |
| Editora | Frontiers Media (PUBLISHER • CH) |
| DOI | 10.3389/fpsyt.2012.00101 |
| PMID | 23227013 |
| PMCID | PMC3512053 |
| OpenAlex | W2118868620 |
| Idioma | EN |
| Citações recebidas | 1 |
| Referências citadas | 8 |
Patients with psychosis display structural brain abnormalities in multiple brain regions. The disorder is characterized by a putative prodromal period called ultra-high-risk (UHR) status, which precedes the onset of full-blown psychotic symptoms. Recent studies on psychosis have focused on this period. Neuroimaging studies of UHR individuals for psychosis have revealed that the structural brain changes observed during the established phases of the disorder are already evident prior to the onset of the illness. Moreover, certain brain regions show extremely dynamic changes during the transition to psychosis. These neurobiological features may be used as prognostic and predictive biomarkers for psychosis. With advances in neuroimaging techniques, neuroimaging studies focusing on gray matter abnormalities provide new insights into the pathophysiology of psychosis, as well as new treatment strategies. Some of these novel approaches involve antioxidants administration, because it is suggested that this treatment may delay the progression of UHR to a full-blown psychosis and prevent progressive structural changes. The present review includes an update on the most recent developments in early intervention strategies for psychosis and potential therapeutic treatments for schizophrenia. First, we provide the basic knowledge of the brain regions associated with structural abnormalities in individuals at UHR. Next, we discuss the feasibility on the use of magnetic resonance imaging (MRI)-biomarkers in clinical practice. Then, we describe potential etiopathological mechanisms underlying structural brain abnormalities in prodromal psychosis. Finally, we discuss the potentials and limitations related to neuroimaging studies in individuals at UHR
Magnetic resonance imaging · Neuroimaging · Prodrome · Psychiatry · Psychosis · Radiology · Schizophrenia (object-oriented programming · Advanced Neuroimaging Techniques and Applications · Functional Brain Connectivity Studies · Medicine · Neuroscience · Psychology · Schizophrenia research and treatment
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| Obras citantes distintas | 1 |
|---|---|
| Citações por ano | 0,2 |
| Intervalo de citações | 2021 - 2021 (1) |
| Velocidade de citação | historical |
| Altamente citado | Não |
| Tipos de citação | Neutras: 1 |