Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality

The microbiota-gut-brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD

Bioinformatics · Biology · Depression (economics · Gut flora · Insomnia · Major depressive disorder · Microbiome · Mood · Pittsburgh Sleep Quality Index · Psychiatry · Sleep (system call · Sleep quality · Subclinical infection · Clinical Psychology · Gut microbiota and health · Medicine · Psychology · Sleep and related disorders · Tryptophan and brain disorders · Immunology · Internal Medicine

• A risk estimation method for depression based on the dysbiosis of intestinal microbiota in Japanese patients

  Open Access•Kana Miyashita, Kana Okuma et al.•Frontiers in Psychiatry•2024

  Incluir item

• Altered functional connectivity strength in chronic insomnia associated with gut microbiota composition and sleep efficiency

  Open Access•Ziwei Chen, Ying Feng et al.•Frontiers in Psychiatry•2022

  Incluir item

• Prevalence of Depression in the Community from 30 Countries between 1994 and 2014

  Open Access•Grace Y Lim, Waikeung Tam et al.•Scientific Reports•2018

  Incluir item

• Sleep and Depression

  Norifumi Tsuno, Alain Besset et al.•The Journal of Clinical Psychiatry•2005

  Incluir item

• Introducing mothur

  Open Access•Patrick D Schloss, Sarah L Westcott et al.•Applied and Environmental…•2009

  Incluir item

• Uparse

  Open Access•R C Edgar•Nature Methods•2013

  Incluir item

• Trimmomatic

  Open Access•Anthony M Bolger, Anthony Bolger et al.•Bioinformatics•2014

  Incluir item

• Validation of the Insomnia Severity Index as an outcome measure for insomnia research

  Open Access•Célyne Bastien•Sleep Medicine•2001

  Incluir item

• The Pittsburgh sleep quality index

  Open Access•Daniel J Buysse, Charles F Reynolds et al.•Psychiatry Research•1989

  Incluir item

• Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women

  Kirsten Tillisch, Emeran A Mayer et al.•Psychosomatic Medicine•2017

  Incluir item

• Bifidobacterium and Lactobacillus Counts in the Gut Microbiota of Patients With Bipolar Disorder and Healthy Controls

  Open Access•Emiko Aizawa, Hirokazu Tsuji et al.•Frontiers in Psychiatry•2019

  Incluir item

• Systematic Review of Gut Microbiota and Major Depression

  Open Access•Stephanie Cheung, Stephanie G Cheung et al.•Frontiers in Psychiatry•2019

  Incluir item