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Evidence for increased DNA damage repair in the postmortem brain of the high stress-response group of schizophrenia

Dados Bibliográficos

ID15519580
AutoresRisa Shishido (Fukushima Medical University), Yasuto Kunii (0000-0003-1569-7819, Fukushima Medical University, autor correspondente), Mizuki Hino (0000-0003-3700-0322, Fukushima Medical University), Ryuta Izumi (0000-0002-8453-3474, Fukushima Medical University), Atsuko Nagaoka (0000-0002-1159-4436, Fukushima Medical University), Hideki Hayashi (0000-0002-4693-9801, Niigata University), Akiyoshi Kakita (0000-0003-4244-0277, Niigata University), Hiroaki Tomita (0000-0003-2628-880X, Tohoku University), Hirooki Yabe (0000-0003-2668-129X, Fukushima Medical University)
Ano2023
Volume14
Páginas1183696-1183696
Data de publicação2023-08-22
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 1664-0640 • E-ISSN: 1664-0640
EditoraFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2023.1183696
PMID37674553
OpenAlexW4386070413
IdiomaEN
Referências citadas59

Our results suggest that there are subgroups of SZ with different degrees of stress impact. Furthermore, the pathophysiology of these subgroups may be associated with DNA damage repair. These results provide new insights into the interactions and heterogeneity between genetic and environmental factors

Biology · DNA damage · Glucocorticoid receptor · Population · Prefrontal cortex · Receptor · Medicine · Neuroinflammation and Neurodegeneration Mechanisms · Neuroscience · Stress Responses and Cortisol · Tryptophan and brain disorders · Endocrinology · Genetics · Internal Medicine

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