Mapping structural covariance networks in children and adolescents with post-traumatic stress disorder after earthquake

For children and adolescents, there is a high risk of developing post-traumatic stress disorder (PTSD) after suffering from catastrophic events. Previous studies have identified brain functionally and subcortical brain volumes structurally abnormalities in this population. However, up till now, researches exploring alterations of regional cortical thickness (CTh) and brain interregional structural covariance networks (SCNs) are scarce. In this cross-sectional study, CTh measures are derived from 3-Tesla Tl-weighted MRI imaging data in a well-characterized combined group of children and adolescents with PTSD after an earthquake ( N = 35) and a traumatized healthy control group ( N = 24). By using surface-based morphometry (SBM) techniques, the regional CTh analysis was conducted. To map interregional SCNs derived from CTh, twenty-five altered brain regions reported in the PTSD population were selected as seeds. Whole-brain SBM analysis discovered a significant thickness reduction in the left medial orbitofrontal cortex for the subjects with PTSD. Similarly, analysis of SCNs associated with "seed" regions primarily located in default mode network (DMN), midline cortex structures, motor cortex, auditory association cortex, limbic system, and visual cortex demonstrated that children and adolescents with PTSD are associated with altered structural covariance with six key regions. This study provides evidence for distinct CTh correlates of PTSD that are present across children and adolescents, suggesting that brain cortical abnormalities related to trauma exposure are present in this population, probably by driving specific symptom clusters associated with disrupted extinction recall mechanisms for fear, episodic memory network and visuospatial attention

Audiology · Brain morphometry · Cognition · Cortex (anatomy · Default mode network · Magnetic resonance imaging · Orbitofrontal cortex · Population · Prefrontal cortex · Traumatic stress · Clinical Psychology · Functional Brain Connectivity Studies · Medicine · Neuroscience · Posttraumatic Stress Disorder Research · Psychology · Traumatic Brain Injury Research

• Diagnostic and Statistical Manual of Mental Disorders

  American Psychiatric Association American Psychiatric Association, Ewer Ewer•Diagnostic And Statistical Manual…•2013

  Incluir item

• Psychometric properties of the PTSD checklist (PCL)

  Open Access•Edward B Blanchard, Jacqueline Jones-Alexander et al.•Behaviour Research and Therapy•1996

  Incluir item

• Childhood trauma and distress tolerance in a trauma-exposed acute-care psychiatric inpatient sample

  Erin C Berenz, Anka A Vujanovic et al.•Psychological Trauma Theory…•2017

  Incluir item

• Meaning-Making Predicts Forgiveness as an Indicator of Posttraumatic Growth with a Stronger Effect for Natural Disasters

  Open Access•Erinn C Cameron, Ani Kalayjian et al.•Journal of Humanistic Psychology•2026

  Incluir item

• Intrusive images in psychological disorders

  Open Access•Chris R Brewin, Gregory James et al.•Psychological Review•2010

  Incluir item