Obsessive–Compulsive Personality Symptoms Predict Poorer Response to Gamma Ventral Capsulotomy for Intractable OCD

Dados Bibliográficos

ID15528809
AutoresMaria Eugênia Copetti (Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, autor correspondente), Antonio Carlos Lopes (0000-0002-3075-6795, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), Guaraci Requena (0000-0001-7554-1600, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), Isaac N S Johnson (0000-0001-8379-3576, Yale University), Benjamin D Greenberg (0000-0002-5648-0002, Brown University), Georg Norén (Brown University), Nicole McLaughlin (0000-0002-4016-2747, Butler Hospital), Roseli Gedanke Shavitt (0000-0001-5959-5748, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), Euripedes Constantino Miguel (0000-0002-9393-3103, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), Marcelo C Batistuzzo (0000-0003-1347-8241, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo), Marcelo Q Hoexter (0000-0002-9302-4380, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, autor correspondente)
Ano2020
Volume10
Páginas936-936
Data de publicação2020-01-08
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Psychiatry (JOURNAL)
Identificadores do periódicoISSN: 1664-0640 • E-ISSN: 1664-0640
EditoraFrontiers Media (PUBLISHER • CH)
DOI10.3389/fpsyt.2019.00936
PMID31998155
OpenAlexW2999998226
IdiomaEN
Referências citadas10

Gamma ventral capsulotomy (GVC) is a radiosurgical procedure which aims to create lesions in the ventral part of the anterior limb of the internal capsule (ALIC). It has been used as a treatment option for patients with intractable obsessive-compulsive disorder (OCD) who do not respond to several first-line treatments attempts. However, changes in personality disorder symptoms after GVC have not been investigated. The aims of this study are to investigate changes in personality disorder symptoms after GVC and to search for baseline personality disorder symptoms that may predict clinical response to GVC. Fourteen treatment-intractable OCD patients who underwent GVC completed the Structured Clinical Interview for DSM-IV Personality Disorders (SCID-II) at baseline and one year after the procedure. Wilcoxon signed-rank test was performed to investigate personality disorder symptom changes before and after surgery. Linear regression models were utilized to predict treatment response, using baseline personality disorder symptoms as independent variables. We did not observe any quantitative changes in personality disorder symptoms after GVC, compared with baseline. Higher severity of obsessive-compulsive personality disorder symptoms at baseline was correlated with worse treatment response after GVC for OCD (β = -0.085, t-value = -2.52, p-value = 0.027). These findings advocate for the safety of the GVC procedure in this specific population of intractable OCD patients, in terms of personality disorder symptom changes. They also highlight the importance of taking into account the severity of obsessive-compulsive personality disorder symptoms when GVC is indicated for intractable OCD patients

Personality · Personality disorders · Psychiatry · Clinical Psychology · Obsessive-Compulsive Spectrum Disorders · Personality Disorders and Psychopathology · Psychology · Sexual function and dysfunction studies