Efficacy of an Internet-Based Intervention for Subclinical Depression (MoodBox) in China

Background: Subclinical depression is a prevalent mental health problem and increases the incidence of the onset of major mood disorders, such as major depressive disorder (MDD). Psychological interventions have been proved to be effective for reducing depressive symptoms for people with subclinical depression and can prevent the onset of MDD. However, people have limited access to face-to-face psychotherapy. Internet-based psychological intervention is an alternative treatment option. The aim of the study is to evaluate the efficacy of MoodBox, an online psychological intervention program, for subclinical depression. Methods: This study is a multicenter, randomized, controlled, non-blinded superiority study with three parallel groups. A total of 435 first-year university students with subclinical depression will be recruited. Eligible participants will be randomly assigned to the MoodBox group, the online psychoeducation group, and the naturalistic observation group at a ratio of 1:1:1. The intervention period is 8 weeks, and participants will be continuously followed up for 1 year. The primary outcome of the study is the efficacy of the intervention, defined as measured by the Patient Health Questionnaire (PHQ-9). Discussion: This is the first study to innovatively develop and test an intervention to improve psychological well-being and decrease the incidence of MDD in a subclinical depression population in China. Once proven effective and acceptable, MoodBox could be potentially integrated into the routine clinical service to facilitate the management for people with subclinical depression. Clinical Trial Registration: The trial is registered with the Chinese Clinical Trial Registry on 21 July 2020 (No. ChiCTR2000034826)

Anxiety · Clinical trial · Depression (economics · Depressive symptoms · Intervention (counseling · Major depressive disorder · Mood · Patient Health Questionnaire · Physical therapy · Population · Psychiatry · Psychoeducation · Psychological intervention · Psychosocial · Randomized controlled trial · Subclinical infection · Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes · Clinical Psychology · Digital Mental Health Interventions · Medicine · Mental Health Research Topics · Internal Medicine

• Adult mental health disorders and their age at onset

  Open Access•Peter Blundell Jones•The British Journal of Psychiatry•2013

  Incluir item

• Development of a new inventory for assessing memories of parental rearing behaviour

  Open Access•C Perris, Lars Jacobsson et al.•Acta Psychiatrica Scandinavica•1980

  Incluir item

• Validity of the Childhood Trauma Questionnaire in an Adolescent Psychiatric Population

  Open Access•David P Bernstein, Taruna Ahluvalia et al.•Journal of the American Academy…•1997

  Incluir item

• Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population

  Open Access•Wenzheng Wang, Qian Bian et al.•General Hospital Psychiatry•2014

  Incluir item

• Resources for mental health

  Open Access•Shekhar Saxena, Graham Thornicroft et al.•The Lancet•2007

  Incluir item

• Validation of the Generalized Anxiety Disorder-7 (GAD-7) among Chinese people with epilepsy

  Open Access•Xin Tong, Dongmei An et al.•Epilepsy Research•2016

  Incluir item

• A Brief Measure for Assessing Generalized Anxiety Disorder

  Robert L Spitzer, Carmen Pérez de los Ríos et al.•A.M.A. Archives of Internal…•2006

  Incluir item

• The PHQ-9

  Kurt Kroenke, Robert L Spitzer et al.•Journal of General Internal…•2001

  Incluir item

• Validation and Utility of a Self-report Version of PRIME-MD The PHQ Primary Care Study

  Robert L Spitzer•JAMA•1999

  Incluir item

• The PHQ-9

  Kurt Kroenke, Robert L Spitzer•Psychiatric Annals•2002

  Incluir item

• Integrated mental health services in China

  Open Access•Di Liang, Vickie M Mays et al.•Health Policy and Planning•2018

  Incluir item

• The inventory of parent and peer attachment

  Open Access•Gay C Armsden, Mark T Greenberg•Journal of Youth and Adolescence•1987

  Incluir item