Evaluación de la susceptibilidad in vitro a esparteína, en cuatro cepas de Mycobacterium tuberculosis
Dados Bibliográficos
| ID | 15533730 |
|---|---|
| Autores | Manuel Hidalgo (0000-0001-6352-2576, Antenor Orrego Private University, autor correspondente), Percy Asmat (0000-0003-1899-4499, Antenor Orrego Private University), Pedro Lezama Asencio (0000-0002-8594-0346, Antenor Orrego Private University), Cynthia Ramos (0000-0003-1739-634X, Antenor Orrego Private University), Carlos Alfonso Chimoy Tuñoque (0000-0003-1333-8919, Private University of Trujillo), Gastón Zolla (0000-0002-0432-1050, Universidad Nacional Agraria La Molina) |
| Ano | 2022 |
| Volume | 39 |
| Fascículo | 1 |
| Páginas | 77-82 |
| Data de publicação | 2022-03-31 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | Revista Peruana de Medicina Experimental y Salud Pública (JOURNAL) |
| Identificadores do periódico | ISSN: 1726-4634 • E-ISSN: 1726-4642 |
| Editora | National Institute of Health of Peru (PUBLISHER • PE) |
| DOI | 10.17843/rpmesp.2022.391.10136 |
| PMID | 35766744 |
| OpenAlex | W4224251072 |
| Idioma | ES |
| Referências citadas | 4 |
Sparteine is an alkaloid with bacteriostatic activity on the genus Mycobacterium. The aim of this study was to evaluate the antimicrobial activity of sparteine on the growth of 4 ATCC strains of Mycobacterium tuberculosis (susceptible, resistant to isoniazid, resistant to rifampicin and multidrug-resistant) in vitro. Validation of bactericidal activity of sparteine sulfate was carried out through an adaptation of the Microscopic-Observation Drug-Susceptibility (MODS) method according to the guidelines of the Peruvian National Health Institute. The results demonstrate that at concentrations of 25; 50 and 100 Mm of sparteine sulfate, there is no development of colony-forming units in any of the 4 evaluated strains. Our results demonstrate the potential in vitro antimicrobial effect of sparteine on multidrug-resistant tuberculosis
Antibiotics · Antimicrobial · Biology · In vitro · Isoniazid · Mycobacterium tuberculosis · Rifampicin · Tuberculosis · Chemistry · Medicine · Mycobacterium research and diagnosis · Tuberculosis Research and Epidemiology · Microbiology
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Tuberculosis en el Perú
Comportamiento clínico de la infección y enfermedad causada por micobacterias no tuberculosas en Latinoamérica
Implementación de un sistema de telediagnóstico de tuberculosis y determinación de multidrogorresistencia basada en el método Mods en Trujillo, Perú
| Velocidade de citação | historical |
|---|---|
| Altamente citado | Não |