A Urinary Marker of Oxidative Stress Covaries Positively With Hostility Among Midlife Community Volunteers

OBJECTIVE: Although not all findings are consistent, growing evidence suggests that individuals high in dispositional hostility are at elevated risk for cardiovascular disease and all-cause mortality; however, the mechanisms of these associations remain unclear. One possibility is that hostility is associated with oxidative stress. Here, we explore relationships between hostility and a measure of systemic oxidative stress among a mid-life sample. METHODS: In a community sample of 223 adults aged 30 to 54 years (86% white, 50% female), oxidative stress was measured as the 24-hour urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG). An abbreviated Cook Medley Hostility Scale was used to measure dimensions of hostility. RESULTS: Regression analyses controlling for demographic characteristics and cardiovascular risk factors showed a positive relationship of 8-OHdG with total hostility (beta = 0.003, p = .03) and hostile affect (beta = 0.018, p < .001). CONCLUSIONS: These findings provide evidence that dispositional hostility, and in particular, hostile affect, covary positively with systemic oxidative stress, raising the possibility that oxidative stress contributes to the pathogenicity of hostile attributes

Hostility · Oxidative stress · Urinary system · Cardiac Health and Mental Health · Clinical Psychology · Health disparities and outcomes · Internal Medicine · Medicine · Psychology · Tryptophan and brain disorders

• The psychology of aggression.

  Arnold H Buss•1961

  Incluir item

• Stress, inflammation and cardiovascular disease

  Open Access•Paul H Black, Lisa D Garbutt•Journal of Psychosomatic Research•2002

  Incluir item

• The pathophysiology of cigarette smoking and cardiovascular disease

  Open Access•John A Ambrose, Rajat S Barua•Journal of the American College…•2004

  Incluir item

• Accelerated telomere shortening in response to life stress

  Open Access•Elissa S Epel, Elizabeth H Blackburn et al.•Proceedings of the National…•2004

  Incluir item

• Effects of Psychological and Social Factors on Organic Disease

  David S Krantz, Melissa K McCeney•Annual Review of Psychology•2002

  Incluir item

• Psychosocial Factors and Cardiovascular Diseases

  Susan A Everson‐rose, Susan A Everson-Rose et al.•Annual Review of Public Health•2005

  Incluir item

• Impact of Psychological Factors on the Pathogenesis of Cardiovascular Disease and Implications for Therapy

  Alan Rozanski, James A Blumenthal et al.•Circulation•1999

  Incluir item

• Physical Activity as an Index of Heart Attack Risk in College Alumni1

  Ralph S Paffenbarger, Alvin L Wing et al.•American Journal of Epidemiology•1978

  Incluir item

• Socioeconomic factors and cardiovascular disease

  G A Kaplan, J E Keil et al.•Circulation•1993

  Incluir item

• Markers of Inflammation and Cardiovascular Disease

  Thomas A Pearson, George A Mensah et al.•Circulation•2003

  Incluir item

• Proposed hostility and Pharisaic-virtue scales for the MMPI.

  Walter Wheeler Cook, Donald M Medley•Journal of Applied Psychology•1954

  Incluir item

• Anger, Hostility, and the Heart

  Aron Wolfe Siegman, Timothy W Smith•Anger, Hostility, and the Heart•2013

  Incluir item

• Patterns of Change in Hostility from College to Midlife in the UNC Alumni Heart Study Predict High-Risk Status

  Ilene C Siegler, Paul T Costa et al.•Psychosomatic Medicine•2003

  Incluir item

• Platelets and coronary heart disease

  Jerome H Markovitz, Karen A Matthews•Psychosomatic Medicine•1991

  Incluir item

• Hostility, Gender, and Cardiac Autonomic Control

  Richard P Sloan, Emilia Bagiella et al.•Psychosomatic Medicine•2001

  Incluir item

• Hostility as a Predictor of Survival in Patients With Coronary Artery Disease

  Stephen H Boyle, Raymond Brady Williams et al.•Psychosomatic Medicine•2004

  Incluir item

• Neuroendocrine, Cardiovascular, and Emotional Responses of Hostile Men

  Edward C Suarez, Cynthia M Kuhn et al.•Psychosomatic Medicine•1998

  Incluir item

• The Cook-Medley hostility scale

  John C Barefoot, Kenneth A Dodge et al.•Psychosomatic Medicine•1989

  Incluir item

• Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression

  Michael J Forlenza, Gale E Miller et al.•Psychosomatic Medicine•2006

  Incluir item

• Cortisol excretion in high and low cynically hostile men

  Mary Katherine Pope, Timothy W Smith•Psychosomatic Medicine•1991

  Incluir item

• Hostility and Urine Norepinephrine Interact to Predict Insulin Resistance

  Jianping Zhang, Raymond Niaura et al.•Psychosomatic Medicine•2006

  Incluir item

• Hostility Is Related to Blunted β-Adrenergic Receptor Responsiveness Among Middle-Aged Women

  Andrew Sherwood, Joel W Hughes et al.•Psychosomatic Medicine•2004

  Incluir item

• Changes in Clinically Relevant Metabolites with Psychological Stress Parameters

  John R Hapuarachchi, Ainsley H Chalmers et al.•Behavioral Medicine•2003

  Incluir item

• A meta-analytic review of research on hostility and physical health

  Todd Q Miller, Timothy W Smith et al.•Psychological Bulletin•1996

  Incluir item