Sociodemographic and psychosocial predictors of longitudinal antiretroviral therapy (ART) adherence among first-time ART initiators in Cape Town, South Africa

Dados Bibliográficos

ID19441913
AutoresAlissa Davis (0000-0003-2084-9741, Columbia University, autor correspondente), Andrea Norcini Pala, Andrea Norcini-Pala (0000-0002-6696-4684, Columbia University), Nadia Nguyen (0000-0002-4376-3783, HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, NY, USA), Reuben N Robbins (0000-0003-0774-2245, HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, NY, USA), John A Joska (0000-0003-4260-1181, University of Cape Town), Hetta Gouse (0000-0001-7885-8363, University of Cape Town), Claude Ann Mellins (0000-0002-1978-7638, HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, NY, USA), Landon Myers (0000-0002-8106-7658, University of Cape Town), Landon Myer (University of Cape Town), Michelle Henry (0000-0001-8244-1421, University of Cape Town), Cheng Shiun Leu (HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, NY, USA), Robert H Remien (0000-0002-3963-3273, HIV Center for Clinical and Behavioral Studies, Columbia University and New York State Psychiatric Institute, New York, NY, USA)
Ano2021
Volume33
Fascículo11
Páginas1394-1403
Data de publicação2021-11-02
Peer ReviewedSim
Open AccessNão
TipoARTICLE
PeriódicoAIDS Care (JOURNAL)
Identificadores do periódicoISSN: 0954-0121 • E-ISSN: 1360-0451
EditoraInforma UK Limited (PUBLISHER • GB)
DOI10.1080/09540121.2020.1798336
PMID32698680
OpenAlexW3045144233
IdiomaEN
Citações recebidas7
Referências citadas63

First-time antiretroviral therapy (ART) initiators may be more vulnerable to poor ART adherence because they may be coping with a new HIV diagnosis, facing logistical challenges to accessing and adhering to ART for the first time, and have not yet developed support networks or the skills to support long-term adherence. We recruited 324 participants in two HIV clinics near Cape Town, South Africa. Sociodemographic/psychosocial factors were measured at baseline and self-reported adherence at the 6 month follow-up. We conducted multivariable regression to determine which baseline factors were associated with 6-month adherence. A better patient-clinic relationship score (OR: 1.08 [95% CI: 1.05-1.11]) was associated with higher adherence. A drug use problem (0.51 [0.29-0.87]), higher social isolation (0.93 [0.87-0.99]), and greater number of years living with HIV before initiating ART (0.92 [0.86-1.00]) were associated with adherence levels below 90%. Patient-clinic relationships and social support are key psycho-social factors in early adherence behavior. Reducing drug use problems through targeted screening and early intervention may improve ART adherence

Antiretroviral therapy · Antiretroviral treatment · Family medicine · Psychiatry · Psychosocial · Psychotherapist · Social support · Viral load · HIV Research and Treatment · HIV, Drug Use, Sexual Risk · HIV/AIDS Research and Interventions · Medicine · Psychology