Genetic position of Valencia (Spain) in the Mediterranean basin according toAlu insertions

In this work, eight human-specific Alu insertion polymorphisms (ACE, TPA25, PV92, APO, FXIIIB, D1, A25, and B65) were typed in 106 unrelated healthy individuals born in the province of Valencia (Spain), with the aim of analyzing the genetic relationships between this region of the Iberian Peninsula and other Mediterranean populations. To that end, Alu data on Eastern European, Western European, and North African populations were compiled from previous studies. The genetic information was stressed by means of genetic distances (R matrix method), nonmetric multidimensional scaling (MDS) and analyses of molecular variance (AMOVA). In Valencia, the most common Alu insertion was APO (0.940), and the least frequent was A25 (0.104). The average gene diversity (GD) computed for the sample examined was comparatively high (0.382). The insertion frequencies estimated for the eight Alu markers were very similar to the mean frequencies calculated for the whole set of populations included in the study, suggesting the hybrid nature of the Valencia's gene pool. MDS and AMOVA results generated from Alu data reveal that the Mediterranean has acted as a strong genetic boundary between the north (Europe) and the south (Northern Africa), resulting in significant gene diversity between the populations of the two regions. Restricted exclusively to the European scope, we suggest the possibility that the Mediterranean could have also acted as a migratory passageway, propitiating the dissemination of cultures and genes between the east and west of Europe and giving rise to some homogenization of gene frequencies among coastal dwelling populations

Alu element · Biology · Evolutionary biology · Gene · Gene pool · Genetic diversity · Genetic variation · Genome · Geography · Human genome · Mediterranean Basin · Mediterranean climate · Peninsula · Population · Demography · Forensic and Genetic Research · Genetic diversity and population structure · Genomic variations and chromosomal abnormalities · Ecology · Genetics

• Genetic Admixture Analysis in the Population of Tacuarembó-Uruguay Using Alu Insertions

  Yasser V Vega-Requena, Vega-Requena Vega-Requena et al.•Human Biology•2019

  Incluir item

• Polymorphic Alu insertions in five North‐West Italian populations

  Open Access•Alfredo Santovito, A Selvaggi et al.•American Journal of Human Biology•2007

  Incluir item

• Alu polymorphisms in the Waorani tribe from the Ecuadorian Amazon reflect the effects of isolation and genetic drift

  Open Access•Luis Gómez‐pérez, Miguel A Alfonso‐sánchez et al.•American Journal of Human Biology•2011

  Incluir item

• Genetic admixture estimates by Alu elements in Afro-Colombian and Mestizo populations from Antioquia, Colombia

  Open Access•Luis Gómez-Pérez, Luis Gómez‐pérez et al.•Annals of Human Biology•2010

  Incluir item

• An investigation of the genetic diversity of the Kerkennah islands and Mahdia (Tunisia) using biparental markers

  Open Access•Sabeh Frigi, Amel Ben Ammar El Gaaied et al.•Annals of Human Biology•2013

  Incluir item

• New insights into the genetic history of Tunisians

  Open Access•Raiya Al Bahri, Esther Esteban et al.•Annals of Human Biology•2008

  Incluir item

• Human Alu Insertion Polymorphisms in North African Populations

  Loth Cherni, Sabeh Frigi et al.•Human Biology•2011

  Incluir item

• Estimación de mestizaje en dos poblaciones venezolanas usando marcadores informativos de ancestralidad y haplogrupos de ADN mitocondrial

  Open Access•Alvaro Rodríguez, Sara Flores-Gutiérrez et al.•Revista Argentina de Antropología…•2021

  Incluir item

• Análisis de la estructura genética del Valle de Traslasierra a partir de inserciones Alu

  Open Access•Gabriela Díaz-Rousseau, Gabriela A Díaz-Rousseau et al.•Revista Argentina de Antropología…•2018

  Incluir item

• Microevolutionary processes due to landscape features in the province of Jujuy (Argentina)

  Open Access•Luis Gómez‐pérez, Miguel A Alfonso‐sánchez et al.•American Journal of Human Biology•2011

  Incluir item

• Questioning the “Melting Pot

  Pedro C Hidalgo, Patricia Mut et al.•Human Biology•2014

  Incluir item

• Multiple Regression and Correlation Extensions of the Mantel Test of Matrix Correspondence

  Peter E Smouse, Jeffrey C Long et al.•Systematic Zoology•1986

  Incluir item

• Analysis of molecular variance inferred from metric distances among DNA haplotypes

  Open Access•Laurent Excoffier, Peter E Smouse et al.•Genetics•1992

  Incluir item

• Radiocarbon evidence for maritime pioneer colonization at the origins of farming in west Mediterranean Europe

  Open Access•João Zilhão•Proceedings of the National…•2001

  Incluir item

• Performing the Exact Test of Hardy-Weinberg Proportion for Multiple Alleles

  Sun‐Wei Guo, Sun Wei Guo et al.•Biometrics•1992

  Incluir item

• Nonmetric Multidimensional Scaling

  Open Access•Joseph B Kruskal•Psychometrika•1964

  Incluir item

• Genetic relationships among Berbers and South Spaniards based on CD4 microsatellite/Alu haplotypes

  Open Access•Esther Esteban, Emili González‐Pérez et al.•Annals of Human Biology•2004

  Incluir item

• Mitochondrial DNA HVRI variation in Balearic populations

  Open Access•A Picornell, L Gómez‐Barbeito et al.•American Journal of Physical…•2005

  Incluir item

• Genetic Analyses in Five Western Mediterranean Populations

  Carmen Tomàs, Antonia Picornell et al.•Human Biology•2001

  Incluir item