Efficiency of Borage Seeds Oil Against Gamma Irradiation-Induced Hepatotoxicity in Male Rats
Possible Antioxidant Activity
Dados Bibliográficos
| ID | 20345740 |
|---|---|
| Autores | Hala A H Khattab (King Abdulaziz University, autor correspondente), Inas Z A Abdallah (Helwan University), Fatimah M Yousef (King Abdulaziz University), Etimad A Huwait, Etimad Huwait (0000-0002-4657-6668, King Abdulaziz University) |
| Ano | 2017 |
| Volume | 14 |
| Fascículo | 4 |
| Páginas | 169-179 |
| Data de publicação | 2017-06-05 |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | African Journal of Traditional Complementary and Alternative Medicines (JOURNAL) |
| Identificadores do periódico | ISSN: 0189-6016 • E-ISSN: 2505-0044 |
| Editora | African Traditional Herbal Medicine Supporters Initiative (ATHMSI) (PUBLISHER) |
| DOI | 10.21010/ajtcam.v14i4.20 |
| PMID | 28638880 |
| OpenAlex | W2623925318 |
| Idioma | EN |
| Referências citadas | 1 |
Background: Borage (Borago officinal L.) is an annual herbaceous plant of great interest because its oil contains a high percentage of -linolenic acid (GLA). The present work was carried out to detect fatty acids composition of the oil extracted from borage seeds (BO) and its potential effectiveness against γ-irradiation- induced hepatotoxicity in male rats. Materials and Methods: GC-MS analysis of fatty acids methyl esters of BO was performed to identify fatty acids composition. Sixty rats were divided into five groups (12 rats each): Control, irradiated; rats were exposed to (6.5 Gy) of whole body γ-radiation, BO (50 mg/kg b.wt), irradiated BO post-treated and irradiated BO prepost-treated. Six rats from each group were sacrificed at two time intervals 7 and 15 days post-irradiation. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) levels, lipids profile, as well as serum and hepatic reduced glutathione (GSH) and lipid peroxide (malondialdehyde) (MDA) levels were assessed. Histopathological examination of liver sections were also carried out. Results: The results showed that the high contents of BO extracted by cold pressing, were linoleic acid (34.23%) and GLA (24.79%). Also, oral administration of BO significantly improved serum levels of liver enzymes, lipids profile, as well as serum and hepatic GSH and MDA levels (p
Antioxidant · Biology · Enzyme · Fatty acid · Glutathione · Linoleic acid · Lipid peroxidation · Lipid peroxide · Malondialdehyde · Chemistry · Edible Oils Quality and Analysis · Fatty Acid Research and Health · Medicine · Sesame and Sesamin Research · Biochemistry · Food Science · Internal Medicine · Pharmacology
| Altamente citado | Não |
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