Gender differences and psychotropic polypharmacy in psychiatric patients in Brazil

A cross-sectional analysis of the Pessoas Project

Dados Bibliográficos

ID21057321
AutoresJuliana De Oliveira Costa (0000-0002-8355-023X, Universidade Federal de Minas Gerais), Maria Das Graças B Ceccato (0000-0002-4340-0659, Universidade Federal de Minas Gerais), Ana Paula Souto Melo (0000-0002-9955-0824, Federal University of São João del-Rei), Francisco De Assis Acurcio (0000-0002-5880-5261, Universidade Federal de Minas Gerais), Mark Drew Crosland Guimarães (0000-0001-7932-3854, Universidade Federal de Minas Gerais)
Ano2017
Volume33
Fascículo4
Páginase00168915-e00168915
Data de publicação2017-01-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoCadernos de Saude Publica (JOURNAL)
Identificadores do periódicoISSN: 0102-311X • E-ISSN: 1678-4464
EditoraFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0102-311x00168915
PMID28538794
OpenAlexW2620416884
SCIELO_PIDS0102-311X2017000405001
IdiomaEN
Citações recebidas2
Referências citadas32

We aimed to estimate the prevalence and correlates of psychotropic polypharmacy in Brazilian psychiatric patients by gender. Sociodemographic, behavioral and clinical data were obtained through face-to-face interviews and medical charts of 2,475 patients. Psychotropic polypharmacy was defined as the use of two or more psychotropic drugs and occurred in 85.7% of men (95%CI: 83.6%-87.6%) and 84.9% of women (95%CI: 82.8%-86.8%; p > 0.05). The mean number of psychotropic drugs/patient was 2.98 ± 1.23 and most common combinations included antipsychotics. Multivariate analysis showed that for both genders, previous hospitalization, severe mental illness, multiple psychiatric diagnoses and an insufficient number of professionals in the health care unit was associated with psychotropic polypharmacy. However, other correlates such as inpatient care, use of non-psychotropic drugs, living in unstable conditions and current smoking vary among them. Psychotropic polypharmacy was a common practice in this national sample. The results highlighted the need for national guidelines to manage patients with mental illness, considering the difference among genders and disease severity, to reduce the burden of polyphamacy in this population

Cross-sectional study · Polypharmacy · Psychiatry · Blood Pressure and Hypertension Studies · Medicine · Mental Health Treatment and Access · Pharmaceutical Practices and Patient Outcomes · Pharmacology · Psychology · Gerontology