“Trust Me, I’m a Doctor.” How TikTok Videos from Different Sources Influence Clinical Trial Participation

This study experiments with TikTok videos to promote clinical trial participation. More specifically, it examines how short-form video sources (doctors vs. prior volunteers for clinical trials) influence perceived source credibility, self-efficacy, and behavioral intention to participate in clinical trials. Findings from this online experiment (N = 396) showed that doctor sources led to greater behavioral intention through enhancing source credibility compared to prior volunteer sources. Alternatively, prior volunteer sources increased behavioral intention via enhanced self-efficacy for participants with low trust in doctors. These findings contribute to the understanding of how short-form video sources act as heuristic cues, leading to persuasion outcomes. Overall, we recommend featuring doctors when using video-based messages to promote clinical trial participation. Also, this study emphasizes the need for health communication practitioners to consider prior volunteers as spokespersons when targeting populations with low baseline trust in doctors

Clinical trial · Credibility · Family medicine · Health communication · MEDLINE · Patient participation · Persuasion · Source credibility · Volunteer · Media Influence and Health · Medicine · Misinformation and Its Impacts · Psychology · Social Media in Health Education · Social Psychology

• Dual-Pathway Mechanisms of Cancer Screening Decisions Among Family Caregivers in China

  Sheng Bao, Yubing Chen•Health Communication•2026

  Incluir item

• Communication and Persuasion

  Open Access•Richard E Petty, John T Cacioppo•Communication and Persuasion•1986

  Incluir item

• Trust in the Medical Profession

  Open Access•Mark A Hall, Fabian Camacho et al.•Health Services Research•2002

  Incluir item

• Closing the Knowledge-Behavior Gap in Health Promotion

  R N Rimal•Health Communication•2000

  Incluir item

• Experimental Methodology in Journalism and Mass Communication Research

  Open Access•Esther Thorson, Rob Wicks et al.•Journalism & Mass Communication…•2012

  Incluir item

• Trust in Physicians and Medical Institutions

  Open Access•Mark A Hall, Elizabeth Dugan et al.•Milbank Quarterly•2001

  Incluir item

• Social-cognitive predictors of health behavior

  Ralf Schwarzer, Britta Renner•Health Psychology•2000

  Incluir item

• The Persuasiveness of Source Credibility

  Open Access•Chanthika Pornpitakpan•Journal of Applied Social…•2004

  Incluir item

• Social Media Use for Health Purposes

  Open Access•Junhan Chen, Yuan Wang•Journal of Medical Internet…•2021

  Incluir item

• Guilt and giving

  Open Access•Debra Z Basil, Nancy M Ridgway et al.•Psychology and Marketing•2008

  Incluir item

• Applying the social cognitive perspective to volunteer intention in China

  Open Access•Jia-Wei Wang, C-N Wei et al.•Health Promotion International•2011

  Incluir item

• “I Thought about It and I May Follow What You Said”

  Open Access•Xialing Lin, Kenneth A Lachlan et al.•Journal of International Crisis…•2022

  Incluir item

• Friends over Doctors? The Influences of Source and Perceived Customization on College Drinking

  Zhaomeng Niu, David C Jeong et al.•Health Communication•2021

  Incluir item

• Effects of Communication Source and Racial Representation in Clinical Trial Recruitment Flyers

  Sungkyoung Lee, Namyeon Lee et al.•Health Communication•2023

  Incluir item

• Testing Strategies to Increase Source Credibility through Strategic Message Design in the Context of Vaccination and Vaccine Hesitancy

  Yiwei Xu, Drew Margolin et al.•Health Communication•2021

  Incluir item

• Do Messages Matter? Investigating the Combined Effects of Framing, Outcome Uncertainty, and Number Format on Covid-19 Vaccination Attitudes and Intention

  Tianen Chen, Minhao Dai et al.•Health Communication•2022

  Incluir item

• Fundamental Processes Leading to Attitude Change

  Open Access•Pablo Briñol, Richard E Petty•Journal of Communication•2006

  Incluir item

• Identity and Persuasion

  Monique A Fleming, Richard E Petty•Attitudes, Behavior, and Social…•1999

  Incluir item

• Conceptualizing sources in online news

  Open Access•Sundar, S S Sundar et al.•Journal of Communication•2001

  Incluir item

• Health Care Avoidance Among Rural Populations

  Open Access•Angela M Spleen, Angela Spleen et al.•The Journal of Rural Health•2014

  Incluir item

• A systematic review and meta-analysis of antecedents of blood donation behavior and intentions

  Open Access•Timothy C Bednall, Liliana L Bove et al.•Social Science & Medicine•2013

  Incluir item

• Message Properties, Mediating States, and Manipulation Checks

  Open Access•Daniel J O’keefe•Communication Theory•2003

  Incluir item

• Goodwill

  James C Mccroskey, Jason J Teven•Communication Monographs•1999

  Incluir item

• The Routledge Handbook of Health Communication

  Teresa L Thompson, Roxanne Parrott et al.•Routledge Handbook of Health…•2011

  Incluir item

• The effects of similarity, parasocial identification, and source credibility in obesity public service announcements on diet and exercise self-efficacy

  Open Access•Joe Phua•Journal of Health Psychology•2016

  Incluir item

• Mobile Persuasion

  Open Access•Ki Joon Kim, Sundar et al.•Human Communication Research•2016

  Incluir item