Association of the Vegf 2578C>A Polymorphism With Metabolic Syndrome and Erectile Dysfunction

Dados Bibliográficos

ID21748367
AutoresChih-I Liu (0000-0001-9193-5749, Kaohsiung Medical University), Chia-Chu Liu (Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan), Chia‐Chu Liu (0000-0001-5797-4613, Kaohsiung Medical University), Shu‐Pin Huang (0000-0003-2968-6125, National Sun Yat-sen University), Shu-Pin Huang (Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan), Jiun‐Hung Geng (0000-0003-0610-1278, Kaohsiung Medical University, autor correspondente), Yung‐Chin Lee (0000-0001-8193-403X, Kaohsiung Medical University), Yung-Chin Lee (Department of Urology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan)
Ano2024
Volume18
Fascículo5
Páginas15579883241282385-15579883241282385
Data de publicação2024-09-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAmerican Journal of Men s Health (JOURNAL)
Identificadores do periódicoISSN: 1557-9883 • E-ISSN: 1557-9891
EditoraSAGE Publications (PUBLISHER • US)
DOI10.1177/15579883241282385
PMID39397482
OpenAlexW4403404255
IdiomaEN
Referências citadas51

Accumulating evidence suggests a link between vascular endothelial growth factor (VEGF), erectile dysfunction (ED), and metabolic syndrome (Mets), possibly because VEGF can alter the physiological pathways involved in the regulation of endothelial cell proliferation. This study aimed to investigate the genetic susceptibility of VEGF 2578C>A polymorphism to the development of ED and Mets. Collected data included five-item International Index of Erectile Function (IIEF-5), components of Mets, and VEGF 2578C>A polymorphism. A total of 596 subjects from Kaohsiung with a mean age of 55.5 years were enrolled, data collection was done at our hospital. Individuals carrying the VEGF 2578 A allele (CA+AA genotypes) demonstrated a higher prevalence of ED compared to those with the CC genotype, with an adjusted odds ratio (OR) of 1.582 (95% confidence interval [95% CI] = 1.123–2.227, p value = 0.009) in multivariate binary regression analysis. Similarly, individuals carrying the VEGF 2578 A allele showed a higher prevalence of Mets compared to those with the CC genotype, with an adjusted OR of 2.461 (95% CI = 1.491–4.064, p value A polymorphism may serve as a common genetic susceptibility factor in the development of both disorders. Further research is warranted to evaluate the mechanisms underlying this association

Allele · Biology · Confidence interval · Erectile dysfunction · Gene · Genotype · Metabolic syndrome · Obesity · Odds ratio · Vascular endothelial growth factor · VEGF receptors · Hormonal and reproductive studies · Medicine · Menopause: Health Impacts and Treatments · Sexual function and dysfunction studies · Endocrinology · Genetics · Internal Medicine