Interventions to increase the uptake and continuation of pre-exposure prophylaxis (PrEP) by adolescent girls and young women at high risk of HIV in low-income and middle-income countries

A scoping review

Dados Bibliográficos

ID21879040
AutoresObinna Ikechukwu Ekwunife (0000-0003-0879-3861, Harvard University, autor correspondente), Izuchukwu Loveth Ejie (0000-0002-2171-5764, Nnamdi Azikiwe University), Valentine Okelu (Nnamdi Azikiwe University), Carol Mita (0000-0003-3059-1369, Harvard University), Oluwale Durosinmi-Eti (John Snow (United States)), Antonia Powell (John Snow (United States)), Molly F Franke (0000-0002-4890-5728, Harvard University)
Ano2022
Volume7
Fascículo12
Páginase009474
Data de publicação2022-12-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoBMJ Global Health (JOURNAL)
Identificadores do periódicoISSN: 2059-7908 • E-ISSN: 2059-7908
EditoraBMJ (PUBLISHER • GB)
DOI10.1136/bmjgh-2022-009474
PMID36593640
OpenAlexW4310904883
IdiomaEN
Citações recebidas12
Referências citadas44

INTRODUCTION: Effective strategies to increase pre-exposure prophylaxis (PrEP) uptake and continuation among adolescent girls and young women (AGYW) who engage in sex work or transactional sex are sparsely reported. We aimed to describe the available evidence on strategies for improving the uptake and continuation of PrEP among AGYW who engage in sex work or transactional sex, or otherwise are at high risk of acquiring HIV, and report their implementation outcomes. METHOD: PubMed, Embase, CINAHL and Global Health were searched for studies describing strategies to increase uptake and continuation of PrEP for HIV prevention among AGYW at high risk of acquiring HIV in low-income and middle-income countries. Two independent reviewers screened citations for inclusion and performed data abstraction. Proctor's framework was used to report the implementation outcomes of the interventions. RESULT: We identified 1046 citations, and reviewed 69 full-text documents, of which we included 11 in the scoping review. A social marketing campaign was used in one study to create demand for PrEP. A decision support tool was used in one study to improve PrEP initiation. SMS reminders (two studies), drug-level feedback (two studies), peer group support (one study) and conditional economic incentives (one study) were used to improve PrEP continuation. Five studies reported adoption outcomes, two of which were high. Four studies reported sustainability outcomes; these were low or moderate. One study found private youth-friendly clinics a better fit for AGYW PrEP delivery compared with public hospitals, and prescription of PrEP by non-study staff in the hospital facility was low. CONCLUSION: Multiple promising interventions have been used to deliver PrEP to AGYW at high risk of acquiring HIV; however, more information is needed to understand how these interventions would likely perform at scale outside of a research context

Continuation · Developing country · Economic growth · Environmental health · Family medicine · Low and middle income countries · Men who have sex with men · Population · Pre-exposure prophylaxis · Psychological intervention · Sex work · Transactional sex · Adolescent Sexual and Reproductive Health · Demography · HIV/AIDS Research and Interventions · Medicine · Nursing · Sex work and related issues