Practical metrics for establishing the health benefits of research to support research prioritisation

INTRODUCTION: We present practical metrics for estimating the expected health benefits of specific research proposals. These can be used by research funders, researchers and healthcare decision-makers within low-income and middle-income countries to support evidence-based research prioritisation. METHODS: The methods require three key assessments: (1) the current level of uncertainty around the endpoints the proposed study will measure; (2) how uncertainty impacts on the health benefits and costs of healthcare programmes and (3) the health opportunity costs imposed by programme costs. Research is valuable because it can improve health by informing the choice of which programmes should be implemented. We provide a Microsoft Excel tool to allow readers to generate estimates of the health benefits of research studies based on these three assessments. The tool can be populated using existing studies, existing cost-effectiveness models and expert opinion. Where such evidence is not available, the tool can quantify the value of research under different assumptions. Estimates of the health benefits of research can be considered alongside research costs, and the consequences of delaying implementation until research reports, to determine whether research is worthwhile. We illustrate the method using a case study of research on HIV self-testing programmes in Malawi. This analysis combines data from the literature with outputs from the HIV synthesis model. RESULTS: For this case study, we found a costing study that could be completed and inform decision making within 1 year offered the highest health benefits (67 000 disability-adjusted life years (DALYs) averted). Research on outcomes improved population health to a lesser extent (12 000 DALYs averted) and only if carried out alongside programme implementation. CONCLUSION: Our work provides a method for estimating the health benefits of research in a practical and timely fashion. This can be used to support accountable use of research funds

Activity-based costing · Actuarial science · Alternative medicine · Business · Cost–benefit analysis · Economic evaluation · Economic growth · Economics · Environmental health · Health care · Health economics · Health services research · Management science · Outcomes research · Political science · Population · Population health · Ethics in Clinical Research · Global Maternal and Child Health · Health Policy Implementation Science · Medicine · Marketing

• Concomitant health benefits package design and research prioritisation

  Open Access•Laëtitia Schmitt, Jessica Ochalek et al.•BMJ Global Health•2021

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• Reshaping Data with the reshape Package

  Open Access•Hadley Wickham•Journal of Statistical Software•2007

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• Data Analysis

  Open Access•Hadley Wickham•Ggplot2•2016

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• Systematic review and meta-analysis of community and facility-based HIV testing to address linkage to care gaps in sub-Saharan Africa

  Open Access•Monisha Sharma, Roger Ying et al.•Nature•2015

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• Estimating health opportunity costs in low-income and middle-income countries

  Open Access•Jessica Ochalek, James Lomas et al.•BMJ Global Health•2018

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• The effectiveness and cost-effectiveness of community-based lay distribution of HIV self-tests in increasing uptake of HIV testing among adults in rural Malawi and rural and peri-urban Zambia

  Open Access•Melissa Neuman, Pitchaya Indravudh et al.•BMC Public Health•2018

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