India’s syndemic of tuberculosis and Covid-19
Dados Bibliográficos
| ID | 21879445 |
|---|---|
| Autores | Rukmini Shrinivasan (Independent Data Journalist, Chennai, India), Saurabh Rane (Survivors Against Tuberculosis, Mumbai, India), Madhukar Pai (0000-0003-3667-4536, McGill University, autor correspondente) |
| Ano | 2020 |
| Volume | 5 |
| Fascículo | 11 |
| Páginas | e003979 |
| Data de publicação | 2020-11-01 |
| Peer Reviewed | Sim |
| Open Access | Sim |
| Tipo | ARTICLE |
| Periódico | BMJ Global Health (JOURNAL) |
| Identificadores do periódico | ISSN: 2059-7908 • E-ISSN: 2059-7908 |
| Editora | BMJ (PUBLISHER • GB) |
| DOI | 10.1136/bmjgh-2020-003979 |
| PMID | 33199280 |
| OpenAlex | W3101931934 |
| Idioma | EN |
| Citações recebidas | 12 |
| Referências citadas | 14 |
Chromatin instability and loss of protein homeostasis (proteostasis) are two well-established hallmarks of aging, which have been considered largely independent of each other. Using microfluidics and single-cell imaging approaches, we observed that, during the replicative aging of S.cerevisiae , proteostasis decline occurred specifically in the fraction of cells with decreased stability at the ribosomal DNA (rDNA) region. A screen of 170 yeast RNA-binding proteins identified ribosomal RNA (rRNA)- binding proteins as the most enriched group that aggregate upon a decrease in rDNA stability. We further found that loss of rDNA stability contributes to age-dependent aggregation of rRNA-binding proteins through aberrant overproduction of rRNAs. These aggregates negatively impact nucleolar integrity and global proteostasis and hence limit cellular lifespan. Our findings reveal a mechanism underlying the interconnection between chromatin instability and proteostasis decline and highlight the importance of cell-to-cell variability in aging processes
Biology · Chromatin · DNA · DNA damage · Gene · Genome instability · Proteostasis · Ribosomal protein · Ribosomal RNA · Ribosome · Ribosome biogenesis · RNA · SARS-CoV-2 and COVID-19 Research · Tuberculosis Research and Epidemiology · Cell Biology · Genetics
Case fatality among people with drug-susceptible TB enrolled in a private health sector TB treatment support program in Bihar, India during the first year of the Covid-19 pandemic
Tuberculosis in times of Covid-19
The long-term impact of the Covid-19 pandemic on tuberculosis care and infection control measures in anti-retroviral therapy (ART) clinics in low- and middle-income countries
Humane shelter at home
What’s in a name? Applying the syndemic perspective to Covid-19 in Ireland
Routine child immunizations in India during the Covid-19 pandemic
If not for this support, I would have left the treatment
Impact of Covid-19 pandemic and anti-pandemic measures on tuberculosis, viral hepatitis, HIV/Aids and malaria–A systematic review
The global impact of Covid-19 on tuberculosis
Impacts of Covid-19-related service disruptions on TB incidence and deaths in Indonesia, Kyrgyzstan, Malawi, Mozambique, and Peru
Use of routine health information systems to monitor disruptions of coverage of maternal, newborn, and child health services during Covid-19
Are There Global Syndemics
| Obras citantes distintas | 12 |
|---|---|
| Citações por ano | 2,4 |
| Intervalo de citações | 2021 - 2025 (5) |
| Velocidade de citação | recent |
| Altamente citado | Não |
| Tipos de citação | Neutras: 10 |