The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection

Dados Bibliográficos

ID22067025
AutoresWei Zhang (0000-0002-5458-9581, Tongji University), Weiwei Wang (0000-0003-1158-7049, Yancheng Third People's Hospital), Weiwei Hou (0000-0002-5921-2724, Tongji University), Chenfei Jiang (Shanghai University of Medicine and Health Sciences), Jingwen Hu (0000-0001-6477-0360, Shanghai University of Medicine and Health Sciences), Li Sun (0000-0002-9084-1318), Liqing Hu (0000-0003-3592-488X, Ningbo First Hospital, autor correspondente), Jian Wu (0000-0002-2297-3335, Suzhou Municipal Hospital, autor correspondente), Anquan Shang (0000-0003-2820-1982, Tongji University, autor correspondente)
Ano2022
Volume10
Páginas923457-923457
Data de publicação2022-07-22
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Public Health (JOURNAL)
Identificadores do periódicoISSN: 2296-2565 • E-ISSN: 2296-2565
EditoraFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2022.923457
PMID35937269
OpenAlexW4286559961
IdiomaEN
Referências citadas35

Objective The purpose of this study is to determine the diagnostic value and net clinical benefit of interleukin-10 (IL-10), interleukin-17 (IL-17), procalcitonin (PCT), and combination tests in patients with sepsis, which will serve as a standard for sepsis early detection. Patients and methods An investigation of 84 sepsis patients and 81 patients with local inflammatory diseases admitted to the ICU of Tongji University Hospital in 2021. In addition to comparing inter-group variability, indicators relevant to sepsis diagnosis and therapy were screened. Results LASSO regression was used to examine PCT, WBC, CRP, IL-10, IFN-, IL-12, and IL-17. Multivariate logistic regression linked IL-10, IL-17, and PCT to sepsis risk. The AUC values of IL-10, IL-17, PCT, and the combination of the three tests were much higher than those of standard laboratory infection indicators. The combined AUC was greater than the sum of IL-10, IL-17, and PCT ( P < 0.05). A clinical decision curve analysis of IL-10, IL-17, PCT, and the three combined tests found that the three combined tests outperformed the individual tests in terms of total clinical benefit rate. To predict the risk of sepsis using IL-10, IL-17, and PCT had an AUC of 0.951, and the model's predicted probability was well matched. An examination of the nomogram model's clinical value demonstrated a considerable net therapeutic benefit between 3 and 87%. Conclusion The IL-10, IL-17, and PCT tests all have a high diagnostic value for patients with sepsis, and the combination of the three tests outperforms the individual tests in terms of diagnostic performance, while the combined tests have a higher overall clinical benefit rate

Intensive care medicine · Sepsis · Inflammation biomarkers and pathways · Medicine · Psoriasis: Treatment and Pathogenesis · Sepsis Diagnosis and Treatment · Immunology