Depressive symptoms and their associations with tuberculosis-related knowledge, attitudes, and practices among patients with multidrug-resistant tuberculosis

Dados Bibliográficos

ID22076789
AutoresBinh Huy Nguyen (Hanoi Lung Hospital), Huy Le Ngoc (Hanoi Medical University, National Lung Hospital), Huy Ngoc Le (0000-0003-2706-4760, Hanoi Lung Hospital), Hoa B Nguyen (Hanoi Lung Hospital), Giang M Le (Hanoi Lung Hospital), Luong V Dinh (Bệnh viện Phổi Trung ương), Luong Dinh (Hanoi Lung Hospital)
Ano2026
Volume14
Data de publicação2026-06-16
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoFrontiers in Public Health (JOURNAL)
Identificadores do periódicoISSN: 2296-2565 • E-ISSN: 2296-2565
EditoraFrontiers Media SA (PUBLISHER • CH)
DOI10.3389/fpubh.2026.1851867
OpenAlexW7164931657
IdiomaEN
Referências citadas22

Objectives To assess the prevalence of depressive symptoms and examine their associations with tuberculosis-related knowledge, attitudes, and practices (KAP) among patients with multidrug-resistant tuberculosis (MDR-TB). Methods A cross-sectional study was conducted among 528 MDR-TB patients. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9), with a score of ≥10 indicating clinically relevant depression. KAP domains were assessed using a structured scoring system. Associations were analyzed using Spearman correlation and multivariable logistic regression. Results The mean PHQ-9 score was 5.32 ± 4.35, and 14.96% of participants ( n = 79) had clinically relevant depressive symptoms. Among them, 57 had moderate, 17 had moderately severe, and 5 had severe symptoms. Multivariable analysis showed that higher attitude scores were associated with lower odds of depression (aOR = 0.936; 95% CI: 0.886–0.990; p = 0.02). Higher practice scores were also strongly associated with reduced depression risk (aOR = 0.837; 95% CI: 0.778–0.901; p < 0.001). Knowledge score was not independently associated with depression ( p = 0.622). Conclusion Depressive symptoms are common among MDR-TB patients and are more strongly linked to attitudes and practices than to knowledge alone. These findings suggest the potential value of integrating mental health screening and behavioral support into MDR-TB management programs to improve comprehensive patient care

Depressive symptoms · Logistic regression · Odds · Odds ratio · Patient Health Questionnaire · Tuberculosis · Diagnosis and treatment of tuberculosis · Mental Health Treatment and Access · Tuberculosis Research and Epidemiology