The concepts of Ludwik Fleck and their application to the eukaryotic cell cycle

Dados Bibliográficos

ID23037726
AutoresStephen Cooper (0000-0002-4397-736X, University of Michigan, autor correspondente)
Ano2017
Volume16
Páginas335-364
Data de publicação2017-12-18
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoStudia Historiae Scientiarum (JOURNAL)
Identificadores do periódicoISSN: 2451-3202 • E-ISSN: 2543-702X
EditoraUniwersytet Jagiellonski - Wydawnictwo Uniwersytetu Jagiellonskiego (PUBLISHER)
DOI10.4467/2543702xshs.17.013.7714
OpenAlexW2904041192
IdiomaEN
Referências citadas66

The concepts of Ludwik Fleck (1896–1961), a microbiologist, historian, and philosopher of medicine, can be used to analyze the conservative nature of scientific ideas. This is discussed and applied to ideas dominant in the understanding of the eukaryotic cell cycle. These are (a) the G1-phase restriction point as a regulatory element of the mammalian cell cycle, (b) the Rate Change Point proposed to exist in fission yeast, and (c) the proposal that a large number of genes are expressed in a cell-cycle-dependent manner.Fleck proposed that scientific ideas become fixed and difficult to change because criticisms of current and dominant models are either ignored or turned to support of the current model. The idea of a thought-collective leading to the stability of scientific ideas is a central theme of the theory of Ludwik Fleck.

Biology · Cell · Cell cycle · Element (criminal law) · Epistemology · Physics · Point (geometry) · Political science · Theme (computing) · Theoretical physics · Bioinformatics and Genomic Networks · Computer Science · Gene expression and cancer classification · Gene Regulatory Network Analysis · Genetics · Law · Mathematics · Philosophy

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