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Containing Pandemic Influenza at the Source

Dados Bibliográficos

ID23314174
AutoresIra M Longini (0000-0002-2780-9382, Emory University, autor correspondente), Azhar Nizam (0000-0001-9995-5920, Emory University), Shufu Xu (Emory University), Kumnuan Ungchusak (Emory University), Wanna Hanshaoworakul (Emory University), Derek A T Cummings (0000-0002-9437-1907, Emory University), M Elizabeth Halloran (0000-0002-3127-1757, Emory University)
Ano2005
Volume309
Fascículo5737
Páginas1083-1087
Data de publicação2005-08-12
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoScience (JOURNAL)
Identificadores do periódicoISSN: 0036-8075 • E-ISSN: 0193-4511
EditoraAmerican Association for the Advancement of Science (AAAS) (PUBLISHER)
DOI10.1126/science.1115717
PMID16079251
OpenAlexW2162707016
IdiomaEN
Citações recebidas72
Referências citadas26

Highly pathogenic avian influenza A (subtype H5N1) is threatening to cause a human pandemic of potentially devastating proportions. We used a stochastic influenza simulation model for rural Southeast Asia to investigate the effectiveness of targeted antiviral prophylaxis, quarantine, and pre-vaccination in containing an emerging influenza strain at the source. If the basic reproductive number ( R 0 ) was below 1.60, our simulations showed that a prepared response with targeted antivirals would have a high probability of containing the disease. In that case, an antiviral agent stockpile on the order of 100,000 to 1 million courses for treatment and prophylaxis would be sufficient. If pre-vaccination occurred, then targeted antiviral prophylaxis could be effective for containing strains with an R 0 as high as 2.1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R 0 as high as 2.4.

Biology · Coronavirus disease 2019 (COVID-19) · Disease · Highly pathogenic · Infectious disease (medical specialty) · Influenza A virus subtype H5N1 · Pandemic · Pandemic influenza · Quarantine · Vaccination · Virus · Animal Disease Management and Epidemiology · COVID-19 epidemiological studies · Immunology · Influenza Virus Research Studies · Internal Medicine · Medicine · Virology

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Obras citantes distintas72
Citações por ano3,6
Intervalo de citações2006 - 2025 (20)
Velocidade de citaçãorecent
Altamente citadoNão
Tipos de citaçãoNeutras: 66
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