Chronic Fatigue Syndrome

A Working Case Definition

Dados Bibliográficos

ID23314489
AutoresGARY P HOLMES (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska, autor correspondente), JONATHAN E KAPLAN (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), NELSON M GANTZ (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Anthony L Komaroff (0000-0001-7672-2518, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), LAWRENCE B SCHONBERGER (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), STEPHEN E STRAUS (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), James F Jones (0000-0002-1997-4257, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), RICHARD E DUBOIS (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), CHARLOTTE CUNNINGHAM-RUNDLES (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Savita Pahwa (0000-0002-4470-4216, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), GIOVANNA TOSATO (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Leonard S Zegans (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), DAVID T PURTILO (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), NATHANIEL BROWN (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), Robert T Schooley (0000-0002-2498-8426, Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska), IRENA BRUS (Atlanta, Georgia; Worcester and Boston, Massachusetts; Bethesda, Maryland; Denver, Colorado; New York and Manhasset, New York; San Francisco, California; and Omaha, Nebraska)
Ano1988
Volume108
Fascículo3
Páginas387-389
Data de publicação1988-03-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAnnals of Internal Medicine (JOURNAL)
Identificadores do periódicoISSN: 0003-4819 • E-ISSN: 1539-3704
EditoraAmerican College of Physicians (PUBLISHER • US)
DOI10.7326/0003-4819-108-3-387
PMID2829679
OpenAlexW2138995305
IdiomaEN
Citações recebidas78
Referências citadas7

The chronic Epstein-Barr virus syndrome is a poorly defined symptom complex characterized primarily by chronic or recurrent debilitating fatigue and various combinations of other symptoms, including sore throat, lymph node pain and tenderness, headache, myalgia, and arthralgias. Although the syndrome has received recent attention, and has been diagnosed in many patients, the chronic Epstein-Barr virus syndrome has not been defined consistently. Despite the name of the syndrome, both the diagnostic value of Epstein-Barr virus serologic tests and the proposed causal relationship between Epstein-Barr virus infection and patients who have been diagnosed with the chronic Epstein-Barr virus syndrome remain doubtful. We propose a new name for the chronic Epstein-Barr virus syndrome--the chronic fatigue syndrome--that more accurately describes this symptom complex as a syndrome of unknown cause characterized primarily by chronic fatigue. We also present a working definition for the chronic fatigue syndrome designed to improve the comparability and reproducibility of clinical research and epidemiologic studies, and to provide a rational basis for evaluating patients who have chronic fatigue of undetermined cause.

Chronic fatigue · Chronic fatigue syndrome · Chronic pain · Intensive care medicine · myalgia · Physical therapy · Sore throat · Virus · Fibromyalgia and Chronic Fatigue Syndrome Research · Immunology · Medicine