More than 50 long-term effects of Covid-19

A systematic review and meta-analysis

Dados Bibliográficos

ID23320199
AutoresSandra Lopez-Leon (0000-0001-7504-3441), Talia Wegman-Ostrosky (0000-0002-3207-6697), Carol Perelman (0000-0002-0111-1154), Rosalinda Sepulveda (0000-0003-1146-9552), Paulina A Rebolledo (0000-0002-9808-063X), Angelica Cuapio (0000-0002-9451-1914), Sonia Villapol (0000-0002-6174-4113)
Ano2021
Volume11
Fascículo1
Data de publicação2021-08-09
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoScientific Reports (JOURNAL)
Identificadores do periódicoISSN: 2045-2322 • E-ISSN: 2045-2322
EditoraSpringer Science and Business Media LLC (PUBLISHER)
DOI10.1038/s41598-021-95565-8
IdiomaEN
Citações recebidas103
Referências citadas51

COVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.