Protection, health seeking, or a laissez-passer

Participants' decision-making in an EVD vaccine trial in the eastern Democratic Republic of the Congo

Dados Bibliográficos

ID4594413
AutoresMyfanwy Vaughan James (0000-0001-7194-1287, London School of Hygiene & Tropical Medicine, autor correspondente), Joseph Grace Kasereka, Benjamin Kasiwa, Hugo Kavunga-Membo (0000-0003-3363-7959, National Institute of Biomedical Research), Kasonia Kambale (0000-0001-5340-7048, London School of Hygiene & Tropical Medicine), Rebecca F Grais (0000-0002-5037-8218, Médecins Sans Frontières), Rebecca Grais, Jean-Jacques Muyembe-Tamfum, Jean‐jacques Muyembé‐tamfum (National Institute of Biomedical Research), Daniel G Bausch (0000-0002-7209-6983, London School of Hygiene & Tropical Medicine), Deborah Watson-Jones (0000-0001-6247-1746, London School of Hygiene & Tropical Medicine), Shelley Susan Lee (0000-0003-0062-7930, London School of Hygiene & Tropical Medicine), Shelley Lee
Ano2023
Volume323
Páginas115833
Data de publicação2023-04-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoSocial Science & Medicine (JOURNAL)
Identificadores do periódicoISSN: 0277-9536 • E-ISSN: 1873-5347
EditoraElsevier BV (PUBLISHER)
DOI10.1016/j.socscimed.2023.115833
PMID36934528
OpenAlexW4324135255
IdiomaEN
Citações recebidas2
Referências citadas28

During the 10th Ebola virus disease (EVD) epidemic in the eastern Democratic Republic of the Congo (DRC) (2018-2020), two experimental EVD vaccines were deployed in North Kivu. This province has been at the centre of conflict in the region for the last 25 years. Amidst ambivalence towards protracted foreign intervention and controversy about introducing two experimental vaccines, the existing literature has focused on mistrust and 'resistance' towards the Ebola response and vaccines. In this article, we examine why people in the eastern DRC did decide to volunteer for a trial of a second EVD vaccine in North Kivu, despite the controversy. Drawing on ethnographic observation, interviews, and focus groups with trial participants conducted between September 2020 and April 2021, we analyse three motivations for participating: protection, health seeking, and expectations surrounding travel requirements. We make three points. First, participation in vaccine trials may be understood locally to have advantages which have not been considered by the trial, because they go beyond medical considerations and are specific to a particular social setting. Second, despite much of the literature focusing on a causal relationship between rumours and 'vaccine hesitancy', some rumours may in fact encourage participation. Third, material objects associated with trial participation - such as participant vaccine cards - can hold social and political meaning beyond the confines of the vaccine clinic, and influence decisions surrounding participation. Empirical investigation of how medical interventions become entangled in political economies is essential to understanding the perceived functions of participation, and thus the reasons why people volunteer in clinical trials. Participants' narratives about their decision-making provide an insight into how international bioethical debates interact with, but may also stand apart from, the situated social and economic realities driving decision-making around clinical trials on the ground. This highlights the need for ethical approaches that foreground the political, social, and economic context

Democracy · Political science · Politics · Ethics in Clinical Research · Law · Medicine · Vaccine Coverage and Hesitancy · Viral Infections and Outbreaks Research