Genome-wide meta-analysis, functional genomics and integrative analyses implicate new risk genes and therapeutic targets for anxiety disorders

Anxiety · Bioinformatics · Biology · Computational biology · Functional genomics · Gene · Genetic architecture · Genetic association · Genome · Genome-wide association study · Genomics · Meta-analysis · Psychiatry · Quantitative trait locus · Single-nucleotide polymorphism · Epigenetics and DNA Methylation · Genetic Associations and Epidemiology · Genetics and Neurodevelopmental Disorders · Medicine · Psychology · Genetics · Internal Medicine

• Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia

  Open Access•Xinglun Dang, Zhaowei Teng et al.•Nature Human Behaviour•2025

  Incluir item

• Cross-ancestry genome-wide association study and systems-level integrative analyses implicate new risk genes and therapeutic targets for depression

  Open Access•Yifan Li, Xinglun Dang et al.•Nature Human Behaviour•2025

  Incluir item

• Plink

  Open Access•Shaun M Purcell, Shaun Purcell et al.•The American Journal of Human…•2007

  Incluir item

• Comorbidity Patterns of Anxiety and Depressive Disorders in a Large Cohort Study

  Femke Lamers, Patricia van Oppen et al.•The Journal of Clinical Psychiatry•2011

  Incluir item

• NIH Image to ImageJ

  Open Access•Caroline A Schneider, Wayne S Rasband et al.•Nature Methods•2012

  Incluir item

• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

  Open Access•Kenneth J Livak, Thomas D Schmittgen•Methods•2001

  Incluir item

• A Review and Meta-Analysis of the Genetic Epidemiology of Anxiety Disorders

  John M Hettema, Michael C Neale et al.•American Journal of Psychiatry•2001

  Incluir item

• The Patient Health Questionnaire Somatic, Anxiety, and Depressive Symptom Scales

  Open Access•Kurt Kroenke, Robert L Spitzer et al.•General Hospital Psychiatry•2010

  Incluir item

• The global burden of mental disorders

  Open Access•R C Kessler, Sergio Aguilar-Gaxiola et al.•Epidemiologia e Psichiatria Sociale•2009

  Incluir item

• Prevalence, Persistence, and Sociodemographic Correlates of DSM-IV Disorders in the National Comorbidity Survey Replication Adolescent Supplement

  Shelli Avenevoli•Archives of General Psychiatry•2012

  Incluir item

• Epidemiology of anxiety disorders in the 21st century

  Open Access•Borwin Bandelow, Sophie Michaelis•Dialogues in Clinical Neuroscience•2015

  Incluir item

• The cross-national epidemiology of social anxiety disorder

  Open Access•WHO World Mental Health Survey Collaborators, Dan J Stein et al.•BMC Medicine•2017

  Incluir item

• An atlas of genetic correlations across human diseases and traits

  Open Access•ReproGen Consortium, Brendan Bulik‐Sullivan et al.•Nature Genetics•2015

  Incluir item

• Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

  Open Access•eQTLGen eQTLGen, Naomi R Wray et al.•Nature Genetics•2018

  Incluir item

• LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

  Open Access•Brendan Bulik‐Sullivan, Brendan K Bulik-Sullivan et al.•Nature Genetics•2015

  Incluir item

• Years of GWAS Discovery

  Open Access•Peter M Visscher, Naomi R Wray et al.•The American Journal of Human…•2017

  Incluir item

• Uncertainty and anticipation in anxiety

  Open Access•Daniel W Grupe, Dan W Grupe et al.•Nature Reviews Neuroscience•2013

  Incluir item

• Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions

  Open Access•David M Howard, Mark J Adams et al.•Nature Neuroscience•2019

  Incluir item

• Functional Neuroimaging of Anxiety

  Amit Etkin, Tor D Wager•American Journal of Psychiatry•2007

  Incluir item

• Prevalence of mental disorders in China

  Open Access•Yueqin Huang, Yu Wang et al.•The Lancet Psychiatry•2019

  Incluir item

• Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017

  Open Access•L James, Spencer L James et al.•The Lancet•2018

  Incluir item

• Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

  Open Access•Jackson G Thorp, Adrian I Campos et al.•Nature Human Behaviour•2021

  Incluir item