Forensic efficiency evaluation of a novel 22-STR panel for kinship testing in Eastern Chinese Han population

Dados Bibliográficos

ID5199263
AutoresMan Chen (0000-0002-9334-5088, Institute of Forensic Science), Fan Yang (0000-0003-2978-7102, Ministry of Public Security), Fengtang Yang (0000-0002-3573-2354, Ministry of Public Security of the People's Republic of China), Zhixiao Gao (Suzhou Research Institute), Weifen Sun (Institute of Forensic Science), Xufeng Chu, Xu-Feng Chu (Institute of Forensic Science), Hui Li (0000-0001-9355-1116, Institute of Forensic Science), Lei Jiang (0000-0001-8884-3624, Institute of Forensic Science), Xiling Liu (0000-0003-1318-6150, Institute of Forensic Science)
Ano2025
Volume10
Fascículo4
Páginasowaf022-owaf022
Data de publicação2025-09-02
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoForensic Sciences Research (JOURNAL)
Identificadores do periódicoISSN: 2471-1411 • E-ISSN: 2096-1790
EditoraTaylor & Francis (PUBLISHER • GB)
DOI10.1093/fsr/owaf022
PMID41601570
OpenAlexW4413932171
IdiomaEN
Referências citadas22

Short tandem repeats have been essential and fundamental genetic markers used in forensic individual discrimination and paternity testing since their discovery, especially those used in the Combined DNA Index System. Nevertheless, in cases of complex kinship identification, such as full-sibling, half-sibling, and uncle-niece relationships, the combined application of additional short tandem repeat loci is necessary to reach reliable identification conclusions. In this study, we evaluated the efficiency of an updated novel short tandem repeat genotyping system for kinship identification in the Eastern Chinese Han population. This 23-plex short tandem repeat system demonstrated strong discrimination power among individuals in the target population, with a combined power of discrimination and cumulative probability of exclusion of 1-2.1071 × 10−27 and 0.999999999800, respectively. When 74 short tandem repeats were used and the threshold log10(likelihood ratio) was set to 4, the system efficiency reached 0.999 9 and 0.707 3 for simulated full-sibling and half-sibling pairs, respectively. Furthermore, in two real secondary kinship identification cases, incorporation of the novel 23-plex short tandem repeat system increased the probabilities of the priori kinship hypotheses from 154.259 5 and 1031.699 5 to 56597.118 4 and 134829.791 5, respectively, yielding reliable identification conclusions. Hence, it is evident that the novel 23-plex short tandem repeat system has notable potential as a tool for forensic kinship identification in the Eastern Chinese Han population and could serve as a complementary set of short tandem repeat loci for the identification of distant kinship

Genealogy · Geography · Kinship · Population · Sociology · Anthropology · Demography · Forensic and Genetic Research · Forensic Anthropology and Bioarchaeology Studies · History