Which antiretroviral regimen is associated with higher adherence in Brazil? A comparison of single, multi, and dolutegravir-based regimens

Dados Bibliográficos

ID5230985
AutoresTarsilla Spezialli Cardoso (0000-0002-8400-1689, Universidade Federal de Minas Gerais), Juliana De Oliveira Costa (0000-0002-8355-023X, Universidade Federal de Minas Gerais), Edna Afonso Reis (0000-0003-1465-9167, Universidade Federal de Minas Gerais), Micheline Rosa Silveira (0000-0001-7002-4428, Universidade Federal de Minas Gerais), Palmira De Fátima Bonolo (0000-0003-2744-7139, Universidade Federal de Minas Gerais), Simone Furtado Dos Santos (0000-0002-2060-5934, Universidade Federal de Minas Gerais), Maria Das Graças B Ceccato (0000-0002-4340-0659, Universidade Federal de Minas Gerais)
Ano2019
Volume35
Fascículo9
Páginase00115518-e00115518
Data de publicação2019-01-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoCadernos de Saude Publica (JOURNAL)
Identificadores do periódicoISSN: 0102-311X • E-ISSN: 1678-4464
EditoraFapUNIFESP (SciELO) (PUBLISHER)
DOI10.1590/0102-311x00115518
PMID31531518
OpenAlexW2972608206
SCIELO_PIDS0102-311X2019001105010
IdiomaEN
Citações recebidas4
Referências citadas31

We evaluated adherence to highly active antiretroviral therapy (HAART) and its associated factors according to the type of regimen in patients initiating treatment in Belo Horizonte, Minas Gerais State, Brazil. We measured adherence using the eight items Morisky Therapeutic Adhesion Scale (MMAS-8) and compared the use of "backbone" tenofovir/lamivudine plus efavirenz one tablet once-daily (STR) or dolutegravir in multi-tablet once-daily (MTR-DTG), or other multi-tablet regimens (MTR-other). We conducted a multivariate logistic regression analysis to address factors associated with adherence. A total of 393 patients were included, 254 used STR, 106 MTR-DTG, and 33 MTR-other. The overall adhesion rate was 44.8% (95%CI: 39.4; 50.1), 50% for MTR-DTG, 43.3% for STR and 39.4% for MTR-other. Multivariate analysis showed a higher chance of adherence among patients using MTR-DTG, those who received and understood counseling about their treatment and with a higher quality of life. Prior use of illicit drugs in the lifetime was associated with poorer adherence. Overall adherence was low, highlighting the need for strategies focusing on counseling about medicines and substance use. Pill burden was not an issue for patients using MTR-DTG once-daily, who achieved better results

Antiretroviral therapy · Dolutegravir · Efavirenz · Family medicine · Human immunodeficiency virus (HIV) · Lamivudine · Logistic regression · Medication adherence · Multivariate analysis · Pill · Regimen · Viral load · Virus · HIV/AIDS drug development and treatment · HIV/AIDS Research and Interventions · Internal Medicine · Medication Adherence and Compliance · Medicine · Pharmacology · Virology