Relationships among genomic ancestry, clinical manifestations, socioeconomic status, and skin color of people with sickle cell disease in the State of Pará, Amazonia, Brazil

Dados Bibliográficos

ID6136290
AutoresAriana Kelly Leandra Silva Da Silva (0000-0002-6343-8259, Universidade Federal do Pará), L Madrigal (0000-0003-0788-3558, University of South Florida), Hilton P Silva (0000-0002-3287-3522, Universidade Federal do Pará)
Ano2020
Fascículo37
Páginas159-176
Data de publicação2020-12-11
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAntropologia Portuguesa (JOURNAL)
Identificadores do periódicoISSN: 0870-0990 • E-ISSN: 2182-7982
EditoraCoimbra University Press (PUBLISHER • PT)
DOI10.14195/2182-7982_37_7
OpenAlexW3111572247
IdiomaEN
Referências citadas10

In Brazil about 3500 children are born annually with Sickle Cell Disease (SCD). In the State of Pará, Amazonia, the prevalence is 1%. This article analyzes the Genomic Ancestry (GA) of patients attending the Regional Blood Center in the capital, Belém, in relation to sex, age, clinical manifestations, income, racism, and skin color. Samples were collected from 60 patients (11− 46 years, 34 of them female), and each individual was analyzed for 61 Ancestry Informative Markers (AIM). Semi-structured interviews were conducted to assess socioeconomic status (SES), self-declared color, perception of racism, and symptoms of SCD. From the 55 participants with conclusive DNA samples, 58.2% presented European, 21.8% Amerindian and 20% African DNA. From all the 60 participants, 86.6% self-classified as black or brown, 61.92% were living in poverty and 72% suffered some form of racism due to SCD and/or their skin color. There was an inverse correlation between wage and number of symptoms in all groups. European ancestry and being female was correlated with a greater number of symptoms. In Pará, SCD involves vulnerabilities such as poverty, severe clinical manifestations without treatment, and effects of racism. These results can be useful to develop public policies and to improve quality of life of people with SCD in Brazil and in other countries with heterogeneous populations

Amazon rainforest · Biology · Disease · Environmental health · Pathology · Political science · Population · Poverty · Racism · Socioeconomic status · Sociology · Demography · Gender Studies · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders · Medicine · Race, Genetics, and Society · Gerontology