Bantu β s cluster haplotype predominates among Brazilian Blacks

Dados Bibliográficos

ID8312142
AutoresMarco Antonio Zago (0000-0002-2840-0650, Clinics Hospital of Ribeirão Preto), Mauro S Figueiredo (Clinics Hospital of Ribeirão Preto), Satie H Ogo (Clinics Hospital of Ribeirão Preto)
Ano1992
Volume88
Fascículo3
Páginas295-298
Data de publicação1992-07-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores do periódicoISSN: 0002-9483 • E-ISSN: 1096-8644
EditoraWiley (PUBLISHER • GB)
DOI10.1002/ajpa.1330880304
PMID1642317
OpenAlexW2055152730
IdiomaEN
Citações recebidas17
Referências citadas20

We describe the combination of polymorphic restriction‐enzyme sites in the β globin gene cluster (haplotypes) for 74 chromosomes from Brazilian Blacks bearing the sickle hemoglobin gene (β s ). The three most common African β s haplotypes account for 67 chromosomes: 49/74 (66.2%) were identified as Central African Republic (CAR or Bantu) type, 17 (23.0%) as Benin, and one as Senegal; seven chromosomes (9.5%) had minor atypical haplotypes. This distribution is different from that observed in the United States or Jamaica, where the Benin haplotype predominates, and results from different patterns of slave trades to North and South Americas. Since the β s gene cluster polymorphisms modulate the severity of sickle cell anemia, this heterogeneity may explain differences of the clinical behavior of the disease in the United States and South America, and should also be considered in relation to other features and diseases. © 1992 Wiley‐Liss, Inc

Bantu languages · Biology · Cell · Cluster (spacecraft) · Gene · Genotype · Geography · Haplotype · Sickle cell anemia · Demography · Forensic and Genetic Research · Genetics · Hemoglobinopathies and Related Disorders · Iron Metabolism and Disorders