Resources for functional genomic studies of health and development in nonhuman primates

Dados Bibliográficos

ID8317121
AutoresAnna J Jasinska (0000-0002-1897-4570, Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences David Geffen School of Medicine, University of California Los Angeles California USA, autor correspondente)
Ano2020
Volume171
FascículoS70
Páginas174-194
Data de publicação2020-05-01
Peer ReviewedSim
Open AccessSim
TipoARTICLE
PeriódicoAmerican Journal of Physical Anthropology (JOURNAL)
Identificadores do periódicoISSN: 0002-9483 • E-ISSN: 1096-8644
EditoraWiley (PUBLISHER • GB)
DOI10.1002/ajpa.24051
PMID32221967
OpenAlexW3013057226
IdiomaEN
Citações recebidas1
Referências citadas181

Primates display a wide range of phenotypic variation underlaid by complex genetically regulated mechanisms. The links among DNA sequence, gene function, and phenotype have been of interest from an evolutionary perspective, to understand functional genome evolution and its phenotypic consequences, and from a biomedical perspective to understand the shared and human‐specific roots of health and disease. Progress in methods for characterizing genetic, transcriptomic, and DNA methylation (DNAm) variation is driving the rapid development of extensive omics resources, which are now increasingly available from humans as well as a growing number of nonhuman primates (NHPs). The fast growth of large‐scale genomic data is driving the emergence of integrated tools and databases, thus facilitating studies of gene functionality across primates. This review describes NHP genomic resources that can aid in exploration of how genes shape primate phenotypes. It focuses on the gene expression trajectories across development in different tissues, the identification of functional genetic variation (including variants deleterious for protein function and regulatory variants modulating gene expression), and DNAm profiles as an emerging tool to understand the process of aging. These resources enable comparative functional genomics approaches to identify species‐specific and primate‐shared gene functionalities associated with health and development

Biology · Computational biology · Copy-number variation · DNA methylation · dNaM · Evolutionary biology · Function (biology) · Functional genomics · Gene · Gene expression · Genome · Genomics · Human genome · Phenotype · Epigenetics and DNA Methylation · Genetics · Genomics and Chromatin Dynamics · Genomics and Rare Diseases

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